Document Detail

A population of prenatally generated cells in the rat paleocortex maintains an immature neuronal phenotype into adulthood.
MedLine Citation:
PMID:  18245040     Owner:  NLM     Status:  MEDLINE    
New neurons in the adult brain transiently express molecules related to neuronal development, such as the polysialylated form of neural cell adhesion molecule, or doublecortin (DCX). These molecules are also expressed by a cell population in the rat paleocortex layer II, whose origin, phenotype, and function are not clearly understood. We have classified most of these cells as a new cell type termed tangled cell. Some cells with the morphology of semilunar-pyramidal transitional neurons were also found among this population, as well as some scarce cells resembling semilunar, pyramidal. and fusiform neurons. We have found that none of these cells in layer II express markers of glial cells, mature, inhibitory, or principal neurons. They appear to be in a prolonged immature state, confirmed by the coexpression of DCX, TOAD/Ulip/CRMP-4, A3 subunit of the cyclic nucleotide-gated channel, or phosphorylated cyclic adenosine monophosphate response element-binding protein. Moreover, most of them lack synaptic contacts, are covered by astroglial lamellae, and fail to express cellular activity markers, such as c-Fos or Arc, and N-methyl-d-aspartate or glucocorticoid receptors. We have found that none of these cells appear to be generated during adulthood or early youth and that most of them have been generated during embryonic development, mainly in E15.5.
María Angeles Gómez-Climent; Esther Castillo-Gómez; Emilio Varea; Ramón Guirado; José Miguel Blasco-Ibáñez; Carlos Crespo; Francisco José Martínez-Guijarro; Juan Nácher
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-31
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  18     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2229-40     Citation Subset:  IM    
Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt., Universitat de València, Spain.
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MeSH Terms
Age Factors
Antimetabolites / pharmacology
Biological Markers / metabolism
Bromodeoxyuridine / pharmacology
Entorhinal Cortex / cytology*,  embryology*
Mice, Inbred Strains
Microscopy, Electron
Neural Cell Adhesion Molecule L1 / metabolism
Neurogenesis / physiology*
Neuroglia / cytology,  metabolism
Pyramidal Cells / cytology*,  metabolism,  ultrastructure
Rats, Sprague-Dawley
Receptors, Glucocorticoid / metabolism
Receptors, N-Methyl-D-Aspartate / metabolism
Sialic Acids / metabolism
Stem Cells / cytology*,  metabolism
Reg. No./Substance:
0/Antimetabolites; 0/Biological Markers; 0/Neural Cell Adhesion Molecule L1; 0/Receptors, Glucocorticoid; 0/Receptors, N-Methyl-D-Aspartate; 0/Sialic Acids; 0/polysialyl neural cell adhesion molecule; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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