| A population of prenatally generated cells in the rat paleocortex maintains an immature neuronal phenotype into adulthood. | |
MedLine Citation:
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PMID: 18245040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New neurons in the adult brain transiently express molecules related to neuronal development, such as the polysialylated form of neural cell adhesion molecule, or doublecortin (DCX). These molecules are also expressed by a cell population in the rat paleocortex layer II, whose origin, phenotype, and function are not clearly understood. We have classified most of these cells as a new cell type termed tangled cell. Some cells with the morphology of semilunar-pyramidal transitional neurons were also found among this population, as well as some scarce cells resembling semilunar, pyramidal. and fusiform neurons. We have found that none of these cells in layer II express markers of glial cells, mature, inhibitory, or principal neurons. They appear to be in a prolonged immature state, confirmed by the coexpression of DCX, TOAD/Ulip/CRMP-4, A3 subunit of the cyclic nucleotide-gated channel, or phosphorylated cyclic adenosine monophosphate response element-binding protein. Moreover, most of them lack synaptic contacts, are covered by astroglial lamellae, and fail to express cellular activity markers, such as c-Fos or Arc, and N-methyl-d-aspartate or glucocorticoid receptors. We have found that none of these cells appear to be generated during adulthood or early youth and that most of them have been generated during embryonic development, mainly in E15.5. |
Authors:
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María Angeles Gómez-Climent; Esther Castillo-Gómez; Emilio Varea; Ramón Guirado; José Miguel Blasco-Ibáñez; Carlos Crespo; Francisco José Martínez-Guijarro; Juan Nácher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-31 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 18 ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 2229-40 Citation Subset: IM |
Affiliation:
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Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt., Universitat de València, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Antimetabolites / pharmacology Biological Markers / metabolism Bromodeoxyuridine / pharmacology Entorhinal Cortex / cytology*, embryology* Female Immunophenotyping Male Mice Mice, Inbred Strains Microscopy, Electron Neural Cell Adhesion Molecule L1 / metabolism Neurogenesis / physiology* Neuroglia / cytology, metabolism Pregnancy Pyramidal Cells / cytology*, metabolism, ultrastructure Rats Rats, Sprague-Dawley Receptors, Glucocorticoid / metabolism Receptors, N-Methyl-D-Aspartate / metabolism Sialic Acids / metabolism Stem Cells / cytology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Biological Markers; 0/Neural Cell Adhesion Molecule L1; 0/Receptors, Glucocorticoid; 0/Receptors, N-Methyl-D-Aspartate; 0/Sialic Acids; 0/polysialyl neural cell adhesion molecule; 59-14-3/Bromodeoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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