Document Detail


A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime.
MedLine Citation:
PMID:  19675583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Familial Mediterranean Fever (FMF) is a recessively inherited systemic autoinflammatory disease caused by mutations in the MEFV gene. The frequency of different disease alleles is extremely high in multiple populations from the Mediterranean region, suggesting heterozygote advantage. Here, we characterize the sequence variation and haplotype structure of the MEFV 3' gene region (from exon 5 to the 3' UTR) in seven human populations. In non-African populations, we observed high levels of nucleotide variation, an excess of intermediate-frequency alleles, reduced population differentiation and a genealogy with two common haplotypes separated by deep branches. These features are suggestive of balancing selection having acted on this region to maintain one or more selected alleles. In line with this finding, an excess of heterozygotes was observed in Europeans and Asians, suggesting an overdominance regime. Our data, together with the earlier demonstration that the MEFV exon 10 has been subjected to episodic positive selection over primate evolution, provide evidence for an adaptive role of nucleotide variation in this gene region. Our data suggest that further studies aimed at clarifying the role of MEFV variants might benefit from the integration of molecular evolutionary and functional analyses.
Authors:
M Fumagalli; R Cagliani; U Pozzoli; S Riva; G P Comi; G Menozzi; N Bresolin; M Sironi
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Publication Detail:
Type:  Journal Article     Date:  2009-08-13
Journal Detail:
Title:  Genes and immunity     Volume:  10     ISSN:  1476-5470     ISO Abbreviation:  Genes Immun.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-02     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  England    
Other Details:
Languages:  eng     Pagination:  678-86     Citation Subset:  IM    
Affiliation:
Scientific Institute IRCCS E. Medea, Bioinformatic Laboratory, Bosisio Parini (LC), Italy.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions
Animals
Cytoskeletal Proteins / genetics*,  immunology
Exons
Familial Mediterranean Fever / genetics*,  immunology
Genetics, Population
Haplotypes
Humans
Pan troglodytes / genetics
Selection, Genetic*
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Cytoskeletal Proteins; 0/marenostrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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