Document Detail

A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancer.
MedLine Citation:
PMID:  17695456     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population-based series of CRC. PATIENTS AND METHODS: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. RESULTS: Patients aged < or =30, < or =40, < or =50 and < or =60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in < or =30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher in patients aged 540 years (18.3%) compared to those aged 41-60 years (6.6%; p<0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p =0.0001) when comparing the same age groups. CONCLUSION: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.
Melinda Morris; Cameron Platell; Barry Iacopetta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  27     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-08-15     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2833-8     Citation Subset:  IM    
School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Western Australia.
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MeSH Terms
Age Factors
Colorectal Neoplasms / genetics*,  pathology*
Genes, p53
Genes, ras
Microsatellite Instability
Middle Aged

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