Document Detail


A population-based study of abdominal wall defects in South Australia and Western Australia.
MedLine Citation:
PMID:  9620564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the prevalence, clinical characteristics, prenatal diagnosis and occurrence of other birth defects with abdominal wall defects in births and terminations of pregnancy in South Australia (SA) and Western Australia (WA) over the period 1980-90. Cases of gastroschisis, exomphalos, bladder exstrophy, cloacal exstrophy and body stalk anomaly were ascertained from the WA Birth Defects Registry (1980-90) and the SA Birth Defects Register (1986-90). The registers are comparable population-based data collections with information on livebirths and stillbirths of at least 400 g birthweight or 20 weeks' gestation, and terminations of pregnancy for fetal abnormality. The prevalence of gastroschisis was 1.65/10,000 births (59 cases) and of exomphalos 2.90/10,000 births (104 cases). There was no significant difference in prevalence of exomphalos or gastroschisis between SA and WA for the years 1986-90. However, if data from WA for the years 1980-85 were included, SA had a significantly higher prevalence of exomphalos (prevalence ratio 1.71, confidence interval [CI] 1.16-2.55), although not of gastroschisis (prevalence ratio 1.35, CI 0.79-2.32). Exomphalos was significantly more common in mothers < 20 years (odds ratio [OR] 2.45, CI 1.22-4.86) and in mothers of 40 years or older (OR 5.65, CI 1.69-16.77). Gastroschisis was more common in younger mothers (OR 8.76, CI 4.02-19.32). Both exomphalos and gastroschisis were associated with low birthweight, prematurity, intrauterine growth retardation and caesarean section. The reason for the higher prevalence of exomphalos in SA than WA was not clear, but may be related to differences in prenatal diagnosis. The association between maternal age < 20 years and exomphalos raises the possibility of common factors in the aetiology of gastroschisis and exomphalos.
Authors:
R Byron-Scott; E Haan; A Chan; C Bower; H Scott; K Clark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  12     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-08-28     Completed Date:  1998-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  136-51     Citation Subset:  IM    
Affiliation:
South Australian Birth Defects Register, Department of Medical Genetics and Epidemiology, Women's and Children's Hospital, North Adelaide.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / abnormalities*
Adult
Bladder Exstrophy / epidemiology
Confidence Intervals
Congenital Abnormalities / epidemiology
Female
Hernia, Umbilical / epidemiology*
Humans
Infant, Newborn
Maternal Age
Odds Ratio
Poisson Distribution
Pregnancy
Prenatal Diagnosis / statistics & numerical data
Prevalence
Registries / statistics & numerical data
Regression Analysis
Risk Factors
South Australia / epidemiology
Umbilical Cord / abnormalities
Western Australia / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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