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A population-based review of tetralogy of fallot with absent pulmonary valve: is prenatal diagnosis really associated with a poor prognosis?
MedLine Citation:
PMID:  22302386     Owner:  NLM     Status:  Publisher    
Objectives: Tetralogy of Fallot with absent pulmonary valve syndrome (TETAPV) is reported to have an extremely poor prognosis in the obstetric literature. Therefore, we sought to determine the clinical outcomes associated with TETAPV and to find out if prenatal diagnosis conferred a poorer prognosis. Methods: All cases of TETAPV diagnosed in British Columbia between 1980 and 2009 were reviewed and grouped according to time of diagnosis, either prenatally (PRENATAL) or postnatally (POSTNATAL). The groups were compared with respect to mortality, respiratory issues, the number of interventions and functional capacity at last follow-up. Results: Eight and 11 patients were included in the PRENATAL and POSTNATAL groups with overall long-term survival of 72% and 82%, respectively. There was no significant difference in mortality, preoperative intubation, number of interventions or functional capacity between groups. Conclusion: This study was a population-based retrospective analysis of TETAPV cases identified over three decades. The prognosis of TETAPV is better than that previously reported in the obstetric literature. This information should be used to guide prenatal counseling. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Yvan Mivelaz; Kenneth I Lim; Christina Templeton; Andrew I Campbell; James E Potts; George G S Sandor
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital and The University of British Columbia, Vancouver, BC, Canada; Current affiliation: Unité de Cardiologie, Département médico-chirurgical de pédiatrie, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
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