Document Detail

A population-based five-year follow-up study of cervical human papillomavirus infection.
MedLine Citation:
PMID:  10992174     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the long-term tendency for cervical human papillomavirus infections to persist in the general population. STUDY DESIGN: From 500 women who participated in a 1991 population-based survey, 90 healthy women with normal results of cytologic examination (women with human papillomavirus deoxyribonucleic acid detected and age-matched control women without human papillomavirus deoxyribonucleic acid detected) were interviewed and examined 5 years later colposcopically, cytologically, and with human papillomavirus serologic testing and human papillomavirus deoxyribonucleic acid testing by polymerase chain reaction with 2 different consensus primer pairs (MY09 and MY11 and GP5(+) and GP6(+)), type-specific polymerase chain reaction, and deoxyribonucleic acid sequencing. RESULTS: The 5-year human papillomavirus clearance rate was 92%. Only human papillomavirus type 16 infections persisted. Colposcopic impression of grade 2 cervical intraepithelial neoplasia was associated with persistent human papillomavirus 16 infection (P <.03). Human papillomavirus detection was associated with sexual history. Human papillomavirus type was the only determinant of human papillomavirus persistence. CONCLUSION: The high clearance rates in a population-based setting with a 5-year follow-up period imply that inclusion of human papillomavirus deoxyribonucleic acid testing in population-based cervical screening programs should target persistent infection.
K Elfgren; M Kalantari; B Moberger; B Hagmar; J Dillner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  183     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Huddinge University Hospital, Huddinge, Sweden.
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MeSH Terms
Antibodies, Viral / blood
Cervical Intraepithelial Neoplasia / pathology,  virology
DNA, Viral / analysis
Follow-Up Studies
Middle Aged
Papillomaviridae* / genetics,  immunology
Papillomavirus Infections*
Polymerase Chain Reaction
Tumor Virus Infections*
Uterine Cervical Diseases / virology*
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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