Document Detail


A population-based five-year follow-up study of cervical human papillomavirus infection.
MedLine Citation:
PMID:  10992174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine the long-term tendency for cervical human papillomavirus infections to persist in the general population. STUDY DESIGN: From 500 women who participated in a 1991 population-based survey, 90 healthy women with normal results of cytologic examination (women with human papillomavirus deoxyribonucleic acid detected and age-matched control women without human papillomavirus deoxyribonucleic acid detected) were interviewed and examined 5 years later colposcopically, cytologically, and with human papillomavirus serologic testing and human papillomavirus deoxyribonucleic acid testing by polymerase chain reaction with 2 different consensus primer pairs (MY09 and MY11 and GP5(+) and GP6(+)), type-specific polymerase chain reaction, and deoxyribonucleic acid sequencing. RESULTS: The 5-year human papillomavirus clearance rate was 92%. Only human papillomavirus type 16 infections persisted. Colposcopic impression of grade 2 cervical intraepithelial neoplasia was associated with persistent human papillomavirus 16 infection (P <.03). Human papillomavirus detection was associated with sexual history. Human papillomavirus type was the only determinant of human papillomavirus persistence. CONCLUSION: The high clearance rates in a population-based setting with a 5-year follow-up period imply that inclusion of human papillomavirus deoxyribonucleic acid testing in population-based cervical screening programs should target persistent infection.
Authors:
K Elfgren; M Kalantari; B Moberger; B Hagmar; J Dillner
Related Documents :
894004 - Flow-microfluorometric analysis of nuclei isolated from various normal and malignant hu...
4814904 - Glial fatty metamorphosis. an abnormal response of premyelin glia frequently accompanyi...
16024284 - Raman spectral analysis of phenoxyacetic acid and some chloro substituted phenoxyacetic...
378944 - Asymmetric transcription of r plasmid nr1 in proteus mirabilis.
853544 - Cambendazole and nondrug macromolecules in tissue residues.
15569264 - Proteasome inhibition increases dna and rna oxidation in astrocyte and neuron cultures.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  183     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Huddinge University Hospital, Huddinge, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood
Cervical Intraepithelial Neoplasia / pathology,  virology
Colposcopy
DNA, Viral / analysis
Female
Follow-Up Studies
Humans
Middle Aged
Papillomaviridae* / genetics,  immunology
Papillomavirus Infections*
Polymerase Chain Reaction
Tumor Virus Infections*
Uterine Cervical Diseases / virology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Low doses of estradiol in combination with gestodene to prevent early postmenopausal bone loss.
Next Document:  Five-year incidence and remission rates of female urinary incontinence in a Swedish population less ...