Document Detail


A population-based evaluation of antenatal diagnosis of orofacial clefts.
MedLine Citation:
PMID:  18333649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the changes in prevalence and antenatal detection of cleft lip with or without cleft palate and isolated cleft palate and to describe the association between anomalies and rates of antenatal diagnosis in Nova Scotia from 1992 to 2002. DESIGN: This population-based cohort study employed the Nova Scotia Atlee Perinatal Database, the Fetal Anomaly Database, and IWK Cleft Palate Database in Halifax, Nova Scotia, Canada. OUTCOME MEASURES: Cleft type, mode of diagnosis, and associated abnormalities of orofacial clefts for liveborn infants, stillbirths, and second trimester terminations of pregnancy between 1992 and 2002 were determined. RESULTS: There were 225 fetuses identified as having orofacial clefts. The overall prevalence of clefts was 2.1 in 1000 live births, and this prevalence did not change with time. The overall antenatal detection of cleft lip with or without cleft palate was 23%; however, there was improvement in detection of cleft lip with or without cleft palate from the years 1992 to 1996 (14%) to the years 1997 to 2002 (30%, p = .02). No isolated cleft palates were detected antenatally. Associated structural anomalies were seen in 34.2% of cases with orofacial clefts, and chromosomal abnormalities were associated with 9.8%. CONCLUSIONS: The prevalence of orofacial clefts in Nova Scotia has not changed from 1992 to 2002. The proportion of antenatally diagnosed cleft lip with or without cleft palate in Nova Scotia is consistent with rates reported in the literature and has increased from 1992 to 2002.
Authors:
Kathleen A Russell; Victoria M Allen; Mary E MacDonald; Kirsten Smith; Linda Dodds
Related Documents :
17429909 - Mode of delivery and threshold retinopathy of prematurity in pre-term elbw neonates.
6837629 - Duplication 6q24 leads to 6qter in an infant from a balanced paternal translocation.
15386289 - Developmental changes in the shape of the supralaryngeal vocal tract in chimpanzees.
12825059 - Retinopathy of prematurity in infants with birth weights greater than 1250 grams.
11695749 - A randomised prospective clinical trial into the effect of infant orthopaedics on maxil...
7230459 - Birth defects related to bendectin use in pregnancy. i. oral clefts and cardiac defects.
24646279 - Neonatal encephalopathy: pre-clinical studies in neuroprotection.
14159459 - Oligosaccharides in infants' faeces.
11809619 - The malnourished baby and infant.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  45     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  D; IM    
Affiliation:
Division of Orthodontics, Faculty of Dentistry, Dalhousie University and IWK Health Centre, 5981 University Avenue, Halifax, Nova Scotia, Canada. Kathy.Russell@Dal.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / epidemiology
Abortion, Induced / statistics & numerical data
Adult
Chromosome Aberrations / statistics & numerical data
Cleft Lip / epidemiology*
Cleft Palate / epidemiology*
Cohort Studies
Databases, Factual
Female
Fetal Diseases / epidemiology*
Gestational Age
Humans
Live Birth / epidemiology
Maternal Age
Nova Scotia / epidemiology
Parity
Population Surveillance
Pregnancy
Prenatal Diagnosis / statistics & numerical data*
Prevalence
Stillbirth / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The structural implications of a unilateral facial skeletal cleft: a three-dimensional finite elemen...
Next Document:  Incidence of oronasal fistulae and velopharyngeal insufficiency after cleft palate repair: an audit ...