| A population-based, cross-sectional comparison of lipid-related indexes for symptoms of atherosclerotic disease. | |
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MedLine Citation:
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PMID: 17027569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current lipid guidelines recommend that therapy be targeted primarily at low-density lipoprotein (LDL) cholesterol, and that other lipid indexes may be used as secondary or supplementary targets. Emerging data have suggested that measures such as non-high-density lipoprotein (HDL) cholesterol, apolipoprotein-B, or the total/HDL cholesterol ratio may be more predictive of cardiovascular risk than LDL cholesterol. We conducted a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey to directly compare the strengths of the associations among various lipid-related indexes and clinical features consistent with atherosclerotic disease. From approximately 9,500 data sets in the overall analysis, the apolipoprotein-B/HDL cholesterol ratio emerged as the strongest correlate (odds ratio 1.177 per 1 mg/dl increment, 95% confidence interval 1.063 to 1.302, p <0.01), followed by the total or non-HDL cholesterol/HDL cholesterol ratio (odds ratio for each 1.070 per 1 mg/dl increment, 95% confidence interval 1.024 to 1.118, p <0.01), followed by the triglyceride/HDL cholesterol ratio (odds ratio 1.033 per 1 mg/dl increment, 95% confidence interval 1.011 to 1.056, p <0.01). Neither LDL cholesterol nor the LDL/HDL cholesterol ratio correlated significantly. Parallel analyses comparing tertile extremes and analyses in subgroups determined by gender, age, and body mass index revealed similar findings. The LDL/HDL cholesterol ratio was only significant for lean patients. In conclusion, these observations add to the published data suggesting that LDL cholesterol may not be the best target of lipid-lowering treatment strategies. |
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Authors:
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Stanley H Hsia; Deyu Pan; Peyton Berookim; Martin L Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-08-28 |
Journal Detail:
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Title: The American journal of cardiology Volume: 98 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-09 Completed Date: 2006-11-24 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1047-52 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA. sthsia@cdrew.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins B
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blood Atherosclerosis / blood* Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Cross-Sectional Studies Demography Female Humans Lipids / blood* Male Nutrition Surveys Odds Ratio Retrospective Studies Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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5-U54-RR014616/RR/NCRR NIH HHS; DK54047/DK/NIDDK NIH HHS; G12RR-03026-11/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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