Document Detail

A population-based case-control study of colorectal cancer in Majorca. I. Dietary factors.
MedLine Citation:
PMID:  2298506     Owner:  NLM     Status:  MEDLINE    
A population-based case-control study was conducted between July 1984 and February 1988 in the Spanish island of Majorca; 286 incident colorectal cancer cases, 295 population controls and 203 hospital controls were interviewed using a food frequency questionnaire. In a multivariate analysis, an increased risk of colon cancer was found for high consumption of fresh meats (RR = 2.87) while a high consumption of cruciferous vegetables afforded protection (RR = 0.48). For rectal cancer an increased risk was associated with dairy products (RR = 3.08) while a protection was afforded by consumption of cruciferae (RR = 0.50). For colorectal cancer, the cereal food group also showed an increase in risk (RR = 1.92). When cases were compared to hospital controls, the effects of cruciferae in colon and rectum and those of dairy products in rectal cancer remained. The magnitude of the RR estimates was decreased for most comparisons, although in general terms the direction of the associations was the same. In addition, univariate analyses of food groups also suggested significant increases in risk of colorectal cancer for increasing consumption of cereals, potatoes, pastry, eggs and number of meals per day. An indication was found of a reduction in risk for consumers of coffee. An analysis based on risk scores was also conducted and a 4-fold increase in the risk of colorectal cancer and a highly significant statistical trend was found for high consumption of fresh meat, dairy products and cereals combined with low consumption of cruciferae.
E Benito; A Obrador; A Stiggelbout; F X Bosch; M Mulet; N Muñoz; J Kaldor
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  45     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-23     Completed Date:  1990-02-23     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Unitat d'Epidemiologia i Registre de Càncer de Mallorca, Misericòrdia, Ciutat de Mallorca, Spain.
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MeSH Terms
Age Factors
Case-Control Studies
Colorectal Neoplasms / epidemiology*,  etiology
Diet / adverse effects*
Diet Surveys
Multivariate Analysis
Risk Factors
Sex Factors
Spain / epidemiology

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