Document Detail


A population-based analysis of the effect of autologous hematopoietic cell transplantation in the treatment of multiple myeloma.
MedLine Citation:
PMID:  23286335     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT This population registry-based study followed all cases of myeloma diagnosed in New South Wales Australia during 2002 to 2005 and compared survival outcomes of those who proceeded to autologous hematopoietic cell transplant (HCT) with those who did not. Data available consisted of demographic details and survival, and did not include disease details or treatment type or response. Of 708 patients, 270 (38%) had HCT. The 5-year overall survival (OS) of HCT recipients was significantly better than those who did not proceed to HCT (62% vs 54%, P=0.003). HCT was a significant favourable risk factor for OS, while age over 60 was an adverse risk factor. However, for patients alive at 1 year from diagnosis, there was no significant difference in survival between HCT and non-HCT patients, suggesting that worse disease biology and/or co-existing morbidities were likely to be major reasons for the poorer outcome for non HCT patients.
Authors:
Ian Nivison-Smith; Judy M Simpson; Anthony J Dodds; David Df Ma; Jeff Szer; Kenneth F Bradstock
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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