| A population-based European cohort study of persistence in newly diagnosed hypertensive patients. | |
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MedLine Citation:
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PMID: 12149663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed the percentage of patients after 1 year who persisted on initially prescribed antihypertensive therapy. Medical records of 2416 patients with newly diagnosed hypertension who were prescribed initial antihypertensive monotherapy by general practitioners in Germany, France, and the United Kingdom were evaluated. Comparisons were made among the angiotensin II receptor antagonist (AIIRA) irbesartan, all other antihypertensive classes (including AIIRAs other than irbesartan), and the AIIRA losartan. Patients initiated on the AIIRA irbesartan scored highest with a persistence rate of 60.8%, followed by patients who received all other AIIRA agents with a persistence rate of 51.3%. Angiotensin-converting enzyme inhibitors, calcium channel blockers, beta-blockers, and losartan were associated with comparable persistence rates, between 42.0% and 49.7%. Patients who received diuretics scored lowest with a persistence rate of 34.4%. Persistence has emerged as an essential factor for blood pressure control. Prescribing an antihypertensive agent that provides a favourable efficacy and tolerability profile may provide greater persistence with therapy and hence a higher level of blood pressure control. |
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Authors:
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J Hasford; A Mimran; W R Simons |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of human hypertension Volume: 16 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-31 Completed Date: 2002-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 569-75 Citation Subset: IM |
Affiliation:
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Department for Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Germany. has@ibe.med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use Antihypertensive Agents / therapeutic use* Biphenyl Compounds / therapeutic use* Calcium Channel Blockers / therapeutic use Cohort Studies Europe / epidemiology Female Humans Hypertension / drug therapy*, epidemiology* Losartan / therapeutic use* Male Middle Aged Receptors, Angiotensin / antagonists & inhibitors*, therapeutic use* Retreatment Tetrazoles / therapeutic use* Treatment Failure* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Calcium Channel Blockers; 0/Receptors, Angiotensin; 0/Tetrazoles; 114798-26-4/Losartan; 138402-11-6/irbesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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