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A population analysis of prescriptions for asthma medications during pregnancy.
MedLine Citation:
PMID:  23063582     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: It is important to control asthma during pregnancy. However, some studies indicate that women stop or change their asthma medications when they become pregnant. OBJECTIVE: We used a population database to analyze changes in prescriptions for asthma medications to patients before, during, and after pregnancy. METHODS: We collected information from a pregnancy database that is part of the population-based pharmacy prescription InterAction Database from the northern Netherlands. Our study cohort comprised 25,709 pregnancies for which prescription data were available. We collected data over a study period of 1 year before pregnancy until 6 months after birth and analyzed data from pregnant women who received at least 1 prescription for asthma medication during the study period (n = 2072), identifying all prescriptions for asthma medication and oral corticosteroids. RESULTS: Prescriptions for asthma medications did not change during pregnancies from 1994-2003. However, during the 2004-2009 period, there was a significant decrease (P = .017) in prescriptions for asthma medications during the first months of pregnancy compared with the months before pregnancy, especially prescriptions of long-acting bronchodilators. Although most asthma prescriptions continued throughout pregnancy, prescriptions for controller therapies were reduced by 30% during the first months of pregnancy. CONCLUSIONS: Many women stop or reduce their use of asthma medications when they become pregnant. Strategies to safely control asthma during pregnancy are needed.
Authors:
Priscilla A Zetstra-van der Woude; J Sebastiaan Vroegop; H Jens Bos; Lolkje T W de Jong-van den Berg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  -     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Unit of Pharmacoepidemiology and Pharmacoeconomy, Department of Pharmacy, University of Groningen, Groningen, The Netherlands. Electronic address: a.p.zetstra-van.der.woude@rug.nl.
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