Document Detail


A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced by elastase.
MedLine Citation:
PMID:  17621032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study evaluates the effect of a novel coil with a polyvinyl alcohol (PVA) core that delivered basic fibroblast growth factor (bFGF) to aneurysms in rabbits induced by elastase. METHODS: PVA was processed to form small threads and inserted into the central core of a primary coil (PVA-core coil). After immersion in saline or bFGF (500 or 2000 mug/ml), PVA-core coils were implanted into elastase-induced aneurysms in rabbits in vivo. Follow-up angiography was performed 4 and 8 weeks after embolization, and the effects were histologically semiquantified according to a grading scale. RESULTS: Follow-up angiography showed that the coils did not compact or protrude and that clots did not form in any group. The score of gross neck healing was significantly higher in the 8-week 2000 bFGF group than in the 8-week PVA coil group (2.7 +/- 0.6 versus 0.0 +/- 0.0, P < 0.05). The dome healing score was significantly higher in the 4-week 2000 bFGF group than that of the 4-week PVA coil group (4.0 +/- 0.0 versus 2.7 +/- 0.6, P < 0.05). Cells positive for alpha-smooth muscle actin densely accumulated in the dome of the aneurysm embolized with PVA-core coils containing bFGF. CONCLUSION: Implantation of the PVA-core coil containing bFGF accelerated tissue growth at the neck as well as in the dome of aneurysms induced by elastase in rabbits. These results suggested that PVA-core coils could prevent the recanalization of embolized aneurysms.
Authors:
Tomoyuki Tsumoto; Hiroyuki Matsumoto; Tomoaki Terada; Mitsuharu Tsuura; Toru Itakura; Tetsuya Hamamoto
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  61     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-6; discussion 166     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan. Ttsumoto@chpnet.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Combined Modality Therapy
Drug Implants / administration & dosage*,  chemistry*
Embolization, Therapeutic / instrumentation*,  methods*
Equipment Design
Equipment Failure Analysis
Fibroblast Growth Factor 2 / administration & dosage*,  chemistry
Intracranial Aneurysm / chemically induced,  therapy*
Pancreatic Elastase
Polyvinyl Alcohol / chemistry*
Rabbits
Treatment Outcome
Chemical
Reg. No./Substance:
0/Drug Implants; 103107-01-3/Fibroblast Growth Factor 2; 9002-89-5/Polyvinyl Alcohol; EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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