Document Detail


The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.
MedLine Citation:
PMID:  17697858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One thousand thirty-eight normal glucose-tolerant and 1031 type 2 diabetic subjects selected from the Chennai Urban Rural Epidemiology Study were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay to investigate the association of rs12255372(G/T) and rs7903146(C/T) polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene with type 2 diabetes mellitus in Asian Indians. The frequency of the "T" allele of both rs12255372(G/T) and rs7903146(C/T) polymorphisms was significantly higher in diabetic subjects (23% and 33%) compared to that in normal glucose-tolerant subjects (19% and 28%; P = .001 and P = .0001, respectively). Logistic regression analysis of the rs12255372(G/T) polymorphism showed that the odds ratio (adjusted for age, sex, and body mass index) was 1.56 (95% confidence interval [CI], 1.03-2.37; P = .034) for the TT genotype and 1.29 (95% CI, 1.06-1.58; P = .011) for the TG genotype when compared with the GG genotype. Adjusted odds ratios for the TT and TC genotypes of the rs7903146(C/T) polymorphism were found to be 1.50 (95% CI, 1.08-2.08; P = .013) and 1.44 (95% CI, 1.18-1.76; P = .0003), respectively, compared with the CC genotype. Normal glucose-tolerant subjects with the TT genotype of rs12255372(G/T) had significantly higher 2-hour plasma glucose levels (mean +/- SD, 6.1 +/- 1.4 mmol/L) than those with the GG genotype (5.6 +/- 1.0 mmol/L, P = .011). Normal glucose-tolerant subjects with the TT genotype of rs7903146(C/T) polymorphism had significantly higher 2-hour plasma glucose levels (mean +/- SD, 6.0 +/- 1.3 mmol/L) than those with the CC genotype (5.6 +/- 1.0 mmol/L, P = .004). In conclusion, the T allele of the rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians.
Authors:
Dhanasekaran Bodhini; Venkatesan Radha; Monalisa Dhar; Nagarajan Narayani; Viswanathan Mohan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  56     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-09     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1174-8     Citation Subset:  IM    
Affiliation:
MDRF-ICMR Advanced Centre for Genomics of Diabetes, Madras Diabetes Research Foundation, Gopalapuram, Chennai, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / genetics*
Blood Glucose / analysis
Diabetes Mellitus, Type 2 / epidemiology,  genetics*
Female
Genetic Predisposition to Disease
Genotype
Humans
India / epidemiology
Linkage (Genetics)*
Male
Middle Aged
Polymorphism, Single Nucleotide*
TCF Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/TCF Transcription Factors; 0/Tcf7L2 transcription factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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