Document Detail


A polymorphism in a staphylococcal enterotoxin receptor gene (T cell receptor BV3 recombination signal sequence) is not associated with unexplained sudden unexpected death in infancy in an Australian cohort.
MedLine Citation:
PMID:  20362046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphisms in genes that influence the expression of toxin receptors could contribute to Sudden Infant Death Syndrome (SIDS) and unexplained Sudden Unexpected Death in Infancy (uSUDI) for which there is evidence of toxin involvement. We aimed to determine whether TCRBV3S1 allele 2 could be involved in a staphylococcal toxic shock hypothesis for uSUDI. Observed frequencies of the TCRBV3S1*2 allele and genotype in 48 Australian uSUDI cases and 96 live comparison infants did not differ. In future the role of other toxin receptor gene polymorphisms deserves investigation.
Authors:
Amanda R Highet; Catherine S Gibson; Paul N Goldwater
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-31
Journal Detail:
Title:  Microbial pathogenesis     Volume:  49     ISSN:  1096-1208     ISO Abbreviation:  Microb. Pathog.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606191     Medline TA:  Microb Pathog     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-3     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Microbiology and Infectious Diseases, SA Pathology at the Women's & Children's Hospital, 72 King William Road, North Adelaide, South Australia, Australia. amanda.highet@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Alleles
Australia
Cohort Studies
Female
Guanylate Cyclase / genetics*
Humans
Infant
Male
Polymorphism, Genetic*
Receptors, Antigen, T-Cell, alpha-beta / genetics*
Receptors, Peptide / genetics*
Sudden Infant Death / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Peptide; 0/TCR Vbeta3 protein, human; EC 4.6.1.2/Guanylate Cyclase; EC 4.6.1.2/enterotoxin receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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