Document Detail


Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.
MedLine Citation:
PMID:  23137230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican mestizos with LN and assess an association with histological classes.
METHODS: We included 24 patients with systemic lupus erythematosus (SLE) without nephropathy, 41 with LN, 144 healthy subjects, and 36 with primary glomerulonephritis (GMN). Three ACE I/D polymorphism genotypes-ID, DD, and II--were detected by PCR using peripheral blood genomic DNA.
RESULTS: Frequencies for II, ID, and DD were 0.29, 0.46, and 0.25 in the SLE group; 0.17, 0.63, and 0.20 in the LN group; 0.14, 0.5, and 0.36 in the GMN group; and 0.26, 0.52, and 0.22 among healthy subjects. The I/D polymorphism distribution according to histological class was class II: 1 II, 3 ID, and 1 DD; class III: 2 II, 10 ID, and 1 DD; class IV: 2 II, 9 ID, and 2 DD; class V: 2 II, 3 ID, and 4 DD; and class VI, 1 II. The histological classes with at least three patients had ID genotype as the most frequent except for class V.
CONCLUSION: No association was identified between I/D polymorphisms of ACE and SLE, LN, or GMN in a Mexican population.
Authors:
Jorge F Topete-Reyes; Javier Soto-Vargas; María C Morán-Moguel; Ingrid P Dávalos-Rodríguez; Eréndira L Chávez-González; Ignacio García-de la Torre; Renato Parra-Michel; Miguel Medina-Pérez; Basilio Jalomo-Martínez; Mario Salazar-Páramo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  35     ISSN:  1532-2513     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-07-09     Revised Date:  2013-08-29    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-80     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología, CUCS, Universidad de Guadalajara, Guadalajara, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Female
Genetic Predisposition to Disease
Genotype
Humans
Lupus Nephritis / enzymology*,  ethnology,  genetics*
Male
Mexican Americans / genetics*
Mutagenesis, Insertional
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Sequence Deletion*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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