| Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans. | |
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MedLine Citation:
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PMID: 23137230 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. Objective: To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican mestizos with LN and assess an association with histological classes. Methods: We included 24 patients with systemic lupus erythematosus (SLE) without nephropathy, 41 with LN, 144 healthy subjects, and 36 with primary glomerulonephritis (GMN). Three ACE I/D polymorphism genotypes-ID, DD, and II-were detected by PCR using peripheral blood genomic DNA. Results: Frequencies for II, ID, and DD were 0.29, 0.46, and 0.25 in the SLE group; 0.17, 0.63, and 0.20 in the LN group; 0.14, 0.5, and 0.36 in the GMN group; and 0.26, 0.52, and 0.22 among healthy subjects. The I/D polymorphism distribution according to histological class was class II: 1 II, 3 ID, and 1 DD; class III: 2 II, 10 ID, and 1 DD; class IV: 2 II, 9 ID, and 2 DD; class V: 2 II, 3 ID, and 4 DD; and class VI, 1 II. The histological classes with at least three patients had ID genotype as the most frequent except for class V. Conclusion: No association was identified between I/D polymorphisms of ACE and SLE, LN, or GMN in a Mexican population. |
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Authors:
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Jorge F Topete-Reyes; Javier Soto-Vargas; María C Morán-Moguel; Ingrid P Dávalos-Rodríguez; Eréndira L Chávez-González; Ignacio García-de la Torre; Renato Parra-Michel; Miguel Medina-Pérez; Basilio Jalomo-Martínez; Mario Salazar-Páramo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 35 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2012-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 174-80 Citation Subset: IM |
Affiliation:
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Doctorado en Inmunología, Departamento de Fisiología, CUCS, Universidad de Guadalajara , Guadalajara , Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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