Document Detail


The polymorphic pattern of somatomedins during human development.
MedLine Citation:
PMID:  3425159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human somatomedins (Sm) are heterogeneous on separation by chromatofocussing. Besides the 'classic' insulin-like growth factor I and II (IGF-I/Sm-C and IGF-II), a number of minor peaks emerge which can be classified as IGF-I/Sm-C-like or as IGF-II-like. The aim of the current study was to investigate whether or not polymorphism of somatomedins is present in individuals and whether or not the polymorphic pattern changes during development. Serum extracts from normal healthy children and adults were fractionated by chromatofocussing and the various somatomedin-like peptides were quantitated by specific radioimmunoassays for IGF-I/Sm-C or IGF-II. The results demonstrate 1) that heterogeneity of somatomedins is a common phenomenon existing in all individuals studied, and 2) that the polymorphic patterns of the IGF-I/Sm-C-family and of the IGF-II-family remain rather stable during development, although minor changes are evident.
Authors:
W F Blum; M B Ranke; B Lechner; J R Bierich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  116     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-08     Completed Date:  1988-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  IM    
Affiliation:
University Children's Hospital, Tübingen, FRG.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging* / metabolism
Child
Child, Preschool
Chromatography, High Pressure Liquid
Female
Humans
Insulin-Like Growth Factor I / genetics,  isolation & purification
Insulin-Like Growth Factor II / genetics,  isolation & purification
Isoelectric Focusing
Male
Polymorphism, Genetic
Protein Binding
Radioimmunoassay
Somatomedins / genetics,  isolation & purification*
Chemical
Reg. No./Substance:
0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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