Document Detail

A polymorphic complex dinucleotide repeat at the telomeric D8S7 locus.
MedLine Citation:
PMID:  1511991     Owner:  NLM     Status:  MEDLINE    
Two cosmids isolated from a flow-sorted chromosome 8 library by hybridization with pSW50 (D8S7) were screened for GT microsatellite sequences. Both contained a positive 900-bp Hind III-Xba I fragment. Sequencing revealed a complex dinucleotide repeat. Flanking oligonucleotide primers were synthesized, and the polymerase chain reaction products produced by these primers were typed within the CEPH panel of families. A two-allele polymorphism was identified that is in linkage disequilibrium with a previously described insertion-deletion polymorphism at this locus.
S Wood; M Schertzer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human heredity     Volume:  42     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:  1992  
Date Detail:
Created Date:  1992-09-28     Completed Date:  1992-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  149-52     Citation Subset:  IM    
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 8*
Deoxyribonuclease HindIII / analysis
Linkage (Genetics) / genetics
Molecular Sequence Data
Oligonucleotides / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Repetitive Sequences, Nucleic Acid / genetics
Telomere / physiology*
Reg. No./Substance:
0/Oligonucleotides; EC 3.1.21.-/Deoxyribonuclease HindIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A novel homozygous missense mutation in the protein C (PROC) gene causing recurrent venous thrombosi...
Next Document:  BF and C3 genetic polymorphisms in Kaingang Indians from southern Brazil.