| A polymeric micelle MRI contrast agent with changeable relaxivity. | |
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MedLine Citation:
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PMID: 16891027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymeric micelles were formed from cationic polymers (polyallylamine or protamine) and anionic block copolymers (poly(ethylene glycol)-b-poly(aspartic acid) derivative) that bound Gd ions providing high contrasts in Magnetic Resonance Imaging (MRI) by shortening the T(1) longitudinal relaxation time of protons of water. The Gd-binding block copolymer alone showed high relaxivity (T(1)-shortening ability) values from 10 to 11 mol(-1) s(-1), while the polymeric micelles exhibited low relaxivity values from 2.1 to 3.6 mol(-1) s(-1). These findings point to the feasibility of a novel MRI contrast agent that selectively provides high contrasts at solid tumor sites owing to a dissociation of the micelle structures, while selective delivery to the tumor sites is achieved in the polymeric micelle form. |
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Authors:
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Emiko Nakamura; Kimiko Makino; Teruo Okano; Tatsuhiro Yamamoto; Masayuki Yokoyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-15 |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 114 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2006-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 325-33 Citation Subset: IM |
Affiliation:
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Tokyo University of Science, Department of Pharmaceutics, 2641 Yamasaki, Noda, Chiba 278-8510, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media
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administration & dosage*,
chemistry Gadolinium DTPA / administration & dosage*, chemistry Magnetic Resonance Imaging* Micelles* Neoplasms / diagnosis Polymers / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Micelles; 0/Polymers; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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