Document Detail

The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium.
MedLine Citation:
PMID:  21602484     Owner:  NLM     Status:  MEDLINE    
Dictyostelium uses a wide array of chemical signals to coordinate differentiation as it switches from a unicellular to a multicellular organism. MPBD, the product of the polyketide synthase encoded by stlA, regulates stalk and spore differentiation by rapidly stimulating the release of the phosphopeptide SDF-1. By analyzing specific mutants affected in MPBD or SDF-1 production, we delineated a signal transduction cascade through the membrane receptor CrlA coupled to Gα1, leading to the inhibition of GskA so that the precursor of SDF-1 is released. It is then processed by the extracellular protease of TagB on prestalk cells. SDF-1 apparently acts through the adenylyl cyclase ACG to activate the cyclic AMP (cAMP)-dependent protein kinase A (PKA) and trigger the production of more SDF-1. This signaling cascade shows similarities to the SDF-2 signaling pathway, which acts later to induce rapid spore encapsulation.
Christophe Anjard; Yongxuan Su; William F Loomis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-20
Journal Detail:
Title:  Eukaryotic cell     Volume:  10     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-06     Completed Date:  2011-12-22     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  956-63     Citation Subset:  IM    
Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093-0368, USA.
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MeSH Terms
ATP-Binding Cassette Transporters / metabolism
Adenylate Cyclase / deficiency,  genetics,  metabolism
Cell Differentiation*
Chemokine CXCL12 / metabolism*
Cyclic AMP / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism
Dictyostelium / cytology,  genetics*,  metabolism*
Phosphopeptides / genetics,  metabolism
Protozoan Proteins / metabolism
Resorcinols / metabolism*
Serine Endopeptidases / metabolism
Signal Transduction*
Spores, Fungal / genetics,  metabolism,  physiology*
Grant Support
Reg. No./Substance:
0/4-methyl-5-pentylbenzene-1,3-diol; 0/Chemokine CXCL12; 0/Phosphopeptides; 0/Protozoan Proteins; 0/Resorcinols; 60-92-4/Cyclic AMP; EC AMP-Dependent Protein Kinases; EC 3.4.16.-/TagB protein, Dictyostelium; EC 3.4.21.-/Serine Endopeptidases; EC Cyclase

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