Document Detail

The POLISMAIL lesson: sublingual immunotherapy may be prescribed also in polysensitized patients.
MedLine Citation:
PMID:  20646360     Owner:  NLM     Status:  MEDLINE    
Polysensitization is a feature of allergic rhinitis (AR) that significantly impairs the quality of life (QoL) of AR patients. Allergen-specific immunotherapy is the only causal therapy for AR. However, the polysensitization phenomenon may represent a crucial obstacle as far as it concerns the choice of the allergen extract which should be used for immunotherapy. Therefore, a real-life based multi-centre study, named POLISMAIL, has been designed which aims at evaluating the behaviour of some allergists managing polysensitized AR patients. The effect of two-year SLIT treatment in those patients was also evaluated. A single allergen extract was used for two-thirds of patients, whereas a mix of two allergens was chosen for the remaining patients. The severity grade of AR and the type of diagnosis were significantly improved by 2-year SLIT. In addition, SLIT significantly improved QoL. Both outcomes confirm that SLIT with one or two allergen extracts achieves a significant improvement in polysensitized patients. In conclusion, the POLISMAIL study demonstrates that polysensitization should not represent a counter-indication for prescribing immunotherapy. The choice to limit SLIT to 1-2 allergen extracts was sufficient and effective in improving symptoms and QoL.
G Ciprandi; C Incorvaia; P Puccinelli; S Scurati; S Masieri; F Frati
Publication Detail:
Type:  Letter; Multicenter Study    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  23     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  637-40     Citation Subset:  IM    
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MeSH Terms
Administration, Sublingual
Desensitization, Immunologic*
Quality of Life
Rhinitis, Allergic, Perennial / psychology,  therapy*
Rhinitis, Allergic, Seasonal / psychology,  therapy*

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