| The polarization of immune cells in the tumour environment by TGFbeta. | |
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MedLine Citation:
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PMID: 20616810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transforming growth factor-beta (TGFbeta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system. This Review covers the effects of TGFbeta on natural killer (NK) cells, dendritic cells, macrophages, neutrophils, CD8(+) and CD4(+) effector and regulatory T cells, and NKT cells in animal tumour models and in patients with cancer. Collectively, many recent studies favour the hypothesis that blocking TGFbeta-induced signalling in the tumour microenvironment enhances antitumour immunity and may be beneficial for cancer therapy. An overview of the current drugs and reagents available for inhibiting TGFbeta-induced signalling and their phase in clinical development is also provided. |
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Authors:
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Richard A Flavell; Shomyseh Sanjabi; Stephen H Wrzesinski; Paula Licona-Limón |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-07-09 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 10 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 554-67 Citation Subset: IM |
Affiliation:
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Yale University School of Medicine, 300 Cedar Street, TAC S-569, PO BOX 208011, New Haven, Connecticut 06520, USA. richard.flavell@yale.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology Cell Polarity / immunology* Cytokines / immunology Dendritic Cells / immunology Hematopoiesis, Extramedullary Humans Immunosuppression Killer Cells, Natural / immunology Macrophages / immunology Neoplasms / immunology*, therapy Neutrophils / immunology Signal Transduction / drug effects T-Lymphocyte Subsets / immunology T-Lymphocytes, Regulatory / immunology Transforming Growth Factor beta / antagonists & inhibitors, immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA121974/CA/NCI NIH HHS; DK051665/DK/NIDDK NIH HHS; P50 CA121974/CA/NCI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cytokines; 0/Transforming Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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