Document Detail

The pneumographic and medical investigation of infants suffering apparent life threatening episodes.
MedLine Citation:
PMID:  1756076     Owner:  NLM     Status:  MEDLINE    
Investigation of 340 babies who suffered from apparent life threatening episodes (ALTE) was performed using pneumographic studies and a variety of medical investigations. A number of medical abnormalities were demonstrated by history or investigation, including gastro-oesophageal reflux (211), airways pathology (17), evidence of fits (25), brain-stem tumour (2), hypoglycaemia (2), respiratory syncytial virus (8) and possible Munchausen by proxy (5). Pneumographic abnormalities were detected in 27 of the 340 infants. Home monitors were used for 135 infants. Future central apnoeas occurred in 20 of the 26 infants on home monitors that had had an abnormal pneumogram, compared with one of the 109 infants on home monitors after a normal pneumogram. Thus pneumograms have a sensitivity and specificity of 95% for predicting central apnoeas in babies who have already suffered an ALTE. The effect of eyeball pressure on the heart rate was measured in 65 babies and was found to cause a brisk drop in heart rate in 32 babies. Twenty-two of the 32 babies had future white apnoeas (usually associated with gastro-oesophageal reflux), compared with five of the 33 babies who had no drop in heart rate in response to eyeball pressure. Thus this test has a sensitivity of 81% and a specificity of 74% at predicting white apnoeas in babies who have already suffered an ALTE.
P M Rahilly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  27     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Sudden Infant Death Clinic, Royal Alexandra Hospital for Children, Camperdown, New South Wales, Australia.
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MeSH Terms
Apnea / diagnosis,  etiology,  physiopathology*
Evaluation Studies as Topic
Follow-Up Studies
Gastroesophageal Reflux / complications
Infant, Newborn
Laryngeal Diseases / complications
Monitoring, Physiologic
Munchausen Syndrome by Proxy
Plethysmography, Impedance
Sensitivity and Specificity
Sleep Apnea Syndromes / diagnosis,  physiopathology
Tracheal Diseases / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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