Document Detail


The platelet storage lesion.
MedLine Citation:
PMID:  19683964     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The continuous increase in the demand for platelet transfusion has necessitated the need to establish standards for determining the quality of platelets during storage. Bacterial contamination of platelet products and deleterious changes in structure and function referred to as the platelet storage lesion (PSL), have restricted the platelet shelf life to 5 days. The PSL and platelet health variables have been well studied and documented. The precise correlation between in vitro assays and in vivo platelet recovery and survival is yet to be established. This review presents an overview of the current understanding of PSL and the novel approaches being developed to negate the storage lesion.
Authors:
Manisha Shrivastava
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Publication Detail:
Type:  Journal Article     Date:  2009-08-15
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  41     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-13     Citation Subset:  T    
Affiliation:
Department of Transfusion Medicine, Bhopal Memorial Hospital and Research Centre, Bhopal 462038, MP, India. manishasdr@gmail.com
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