Document Detail


The platelet hyporeactivity of extremely low birth weight neonates is age-dependent.
MedLine Citation:
PMID:  19026437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We have previously demonstrated that, as compared to adults, the platelets of extremely low birth weight (ELBW) neonates are markedly hyporeactive on day 0-1 of life. The purpose of this study was to examine the age dependency of this hyporeactivity. MATERIALS AND METHODS: On days 0-1, 3-4, and 10-14, peripheral blood was collected from 14 stable ELBW neonates and compared to peripheral blood from normal adults run in parallel. Whole blood flow cytometry was used to examine the activation-dependent increase in platelet surface P-selectin (reflecting degranulation) and platelet surface binding of factor V/Va (reflecting platelet surface procoagulant activity) and decrease in platelet surface glycoprotein (GP) Ib (the von Willebrand factor receptor). RESULTS: In the physiologic milieu of whole blood, ELBW neonatal platelets on days 0-1 and 3-4 were markedly less reactive than adult platelets. However, by day 10-14, the platelet function of ELBW neonates improved significantly, although not completely to adult levels. CONCLUSIONS: The age-dependent platelet hyporeactivity of ELBW neonates demonstrated in this study may be a contributing factor to the similar age-dependent propensity of ELBW neonates to intraventricular hemorrhage.
Authors:
Francis J Bednarek; Stephen Bean; Marc R Barnard; A L Frelinger; Alan D Michelson
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-11-20
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Affiliation:
Neonatology, Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Blood Platelets / metabolism*
Factor V / metabolism*
Factor Va / metabolism*
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
P-Selectin / metabolism*
Platelet Glycoprotein GPIb-IX Complex / metabolism*
Chemical
Reg. No./Substance:
0/P-Selectin; 0/Platelet Glycoprotein GPIb-IX Complex; 65522-14-7/Factor Va; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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