Document Detail

The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling.
MedLine Citation:
PMID:  18441387     Owner:  NLM     Status:  MEDLINE    
Endogenous platelet activating factor (PAF) is involved in heart ischemic preconditioning. PAF can also afford pharmacological preconditioning. We studied whether mitochondrial-ATP-sensitive K(+) (mK(ATP)) channels and reactive oxygen species (ROS) are involved in PAF-induced cardioprotection. In Group 1 control hearts, Langendorff-perfused rat hearts underwent 30 min ischemia and 2 hours of reperfusion. Group 2 hearts, before ischemia, were perfused for 19 min with PAF (2x10(-11) M); Groups 3 and 4 hearts were co-infused with PAF and N-acetyl-L-cysteine or 5-hydroxydecanoate to scavenge ROS or to block mK(ATP) channels, respectively. Left ventricular pressure and infarct size were determined. PAF-pretreatment reduced infarct size (33 +/- 4% vs 64 +/- 4.6 % of the area at risk of control hearts) and improved pressure recovery. Infarct-sparing effect of PAF was abolished by N-acetyl-L-cysteine and 5-hydroxydecanoate. Thus, the cardioprotective effect exerted by PAF-pretreatment involves activation of mK(ATP) channels and redox signaling in pre-ischemic phase.
C Penna; B Mognetti; F Tullio; D Gattullo; D Mancardi; P Pagliaro; G Alloatti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  59     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Laboratories of Physiology, Department of Clinical and Biological Sciences, University of Turin, Italy.
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MeSH Terms
Blood Pressure / drug effects
Cardiotonic Agents / pharmacology*
Ischemic Preconditioning, Myocardial / methods*
Myocardial Infarction / prevention & control
Myocardial Reperfusion Injury
Oxidation-Reduction / drug effects
Platelet Activating Factor / pharmacology*
Potassium Channels / drug effects,  metabolism*
Random Allocation
Rats, Wistar
Reactive Oxygen Species / metabolism
Signal Transduction / drug effects
Reg. No./Substance:
0/Cardiotonic Agents; 0/Platelet Activating Factor; 0/Potassium Channels; 0/Reactive Oxygen Species; 0/mitochondrial K(ATP) channel

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