| The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. | |
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MedLine Citation:
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PMID: 18441387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous platelet activating factor (PAF) is involved in heart ischemic preconditioning. PAF can also afford pharmacological preconditioning. We studied whether mitochondrial-ATP-sensitive K(+) (mK(ATP)) channels and reactive oxygen species (ROS) are involved in PAF-induced cardioprotection. In Group 1 control hearts, Langendorff-perfused rat hearts underwent 30 min ischemia and 2 hours of reperfusion. Group 2 hearts, before ischemia, were perfused for 19 min with PAF (2x10(-11) M); Groups 3 and 4 hearts were co-infused with PAF and N-acetyl-L-cysteine or 5-hydroxydecanoate to scavenge ROS or to block mK(ATP) channels, respectively. Left ventricular pressure and infarct size were determined. PAF-pretreatment reduced infarct size (33 +/- 4% vs 64 +/- 4.6 % of the area at risk of control hearts) and improved pressure recovery. Infarct-sparing effect of PAF was abolished by N-acetyl-L-cysteine and 5-hydroxydecanoate. Thus, the cardioprotective effect exerted by PAF-pretreatment involves activation of mK(ATP) channels and redox signaling in pre-ischemic phase. |
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Authors:
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C Penna; B Mognetti; F Tullio; D Gattullo; D Mancardi; P Pagliaro; G Alloatti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 59 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-28 Completed Date: 2008-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 47-54 Citation Subset: IM |
Affiliation:
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Laboratories of Physiology, Department of Clinical and Biological Sciences, University of Turin, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiotonic Agents / pharmacology* Ischemic Preconditioning, Myocardial / methods* Male Myocardial Infarction / prevention & control Myocardial Reperfusion Injury Oxidation-Reduction / drug effects Platelet Activating Factor / pharmacology* Potassium Channels / drug effects, metabolism* Random Allocation Rats Rats, Wistar Reactive Oxygen Species / metabolism Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Platelet Activating Factor; 0/Potassium Channels; 0/Reactive Oxygen Species; 0/mitochondrial K(ATP) channel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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