Document Detail


The plasmablast-like leukocyte in the kidney of fugu (Takifugu rubripes).
MedLine Citation:
PMID:  21216292     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In teleosts, the kidney is the major immune organ. From the kidney of fugu (Takifugu rubripes), we isolated a unique leukocyte population. This population shows properties similar to those of mammalian plasmablasts. First, adherent cells expressing IgM protein on their surface were obtained from the fugu kidney. Flow cytometry (FCM) showed that these cells were mainly composed of two cell populations: IgM(+)CD8α(-) cells and IgM(+)CD8α(+) cells. Further characterization of the IgM(+)CD8α(-) population by RT-PCR demonstrated that the cells expressed secretory-type IgM as well as Bcl-6 and Blimp-1, developmental marker genes for the B cell lineage. Western blotting also showed that the cells secreted IgM protein. These results indicate that the IgM(+)CD8α(-) cells are similar to cells at the plasmablast stage in mammals. This is the first report isolating plasmablast-like leukocytes in fish species. Our data also suggests that the teleosts kidney is a organ where B cells terminally differentiate into the plasma cells.
Authors:
Tomoyuki Odaka; Shigeyuki Tsutsui; Ryuichi Sugamata; Hiroaki Suetake; Toshiaki Miyadai; Yuzuru Suzuki; Tasuku Watanabe; Osamu Nakamura
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Fish & shellfish immunology     Volume:  -     ISSN:  1095-9947     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505220     Medline TA:  Fish Shellfish Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
School of Marine Biosciences, Kitasato University, Sanriku, Ofunato, Iwate 022-0101, Japan.
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