Document Detail

The plasma membrane transformation of uterine epithelial cells during pregnancy.
MedLine Citation:
PMID:  10889831     Owner:  NLM     Status:  MEDLINE    
This review discusses the diversity of placentation mechanisms and examines the extensive alterations that occur in the plasma membrane of uterine epithelial cells during early pregnancy in many species. Ultrastructural, biochemical and morphological studies reveal that similar membrane alterations occur in many species, despite the diversity in the type of placenta that is formed ultimately. As these morphological and molecular alterations in the plasma membrane occur across species and are found basolaterally as well as apically, the term 'plasma membrane transformation' is proposed, which also emphasizes that alterations in this membrane during early pregnancy are not just an occurrence at attachment, but are an ongoing process during much of early pregnancy.
C R Murphy
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reproduction and fertility. Supplement     Volume:  55     ISSN:  0449-3087     ISO Abbreviation:  J. Reprod. Fertil. Suppl.     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-20     Completed Date:  2000-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0225652     Medline TA:  J Reprod Fertil Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
Department of Anatomy and Histology, University of Sydney, NSW, Australia.
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MeSH Terms
Cell Adhesion
Cell Membrane / metabolism,  ultrastructure
Cholesterol / metabolism
Embryo Implantation / physiology*
Epithelial Cells / metabolism,  ultrastructure
Mucin-1 / metabolism
Pregnancy Trimester, First
Uterus / metabolism,  ultrastructure*
Reg. No./Substance:
0/Mucin-1; 57-88-5/Cholesterol

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