| The plasma level of some amino acids and physical and mental fatigue. | |
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MedLine Citation:
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PMID: 8641376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tryptophan is converted to 5-hydroxytryptamine (5-HT) in the brain and evidence is presented that an increase in the concentration of 5-HT can result in physical and mental fatigue during prolonged exercise. The entry of tryptophan in the brain is influenced by the plasma level of free tryptophan (that not bound to albumin) and, from competition for entry into brain, by the plasma level of branched chain amino acids. Hence, oral administration of branched chain amino acids could, theoretically, prevent the increase in 5-HT level during exercise and therefore delay physical and mental fatigue. Evidence in support of this hypothesis is presented. |
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Authors:
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E A Newsholme; E Blomstrand |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experientia Volume: 52 ISSN: 0014-4754 ISO Abbreviation: Experientia Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-07-15 Completed Date: 1996-07-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376547 Medline TA: Experientia Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 413-5 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Oxford, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Animals Brain / physiology* Fatigue* Humans Mental Fatigue* Models, Biological Physical Exertion* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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