| The plasma free fatty acid rebound induced by nicotinic acid. | |
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MedLine Citation:
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PMID: 6038564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The time course of the nicotinic acid-induced changes in levels of plasma free fatty acids (FFA) was examined. The plasma FFA response of fasted dogs to graded doses of nicotinic acid was shown to be biphasic: an initial depression of the level of plasma FFA was followed by a rebound elevation to supernormal levels. FFA rebound was not seen after the administration of the nicotinic acid homologue, pyridylacetic acid, or a variety of nicotinic acid metabolities. A similar pattern of FFA response was observed in fasted, normal rats. Adrenalectomy did not abolish the secondary elevation of FFA but did cause a somewhat delayed response. Hypophysectomy modified the time course of the response-the initial FFA decrease was prolonged-and the intensity of the FFA rebound was diminished. No rebound was observed in hypophysectomized, adrenalectomized rats. In normal rats, nicotinic acid caused a significant rise in the level of plasma corticosterone. A normal rebound pattern was observed in thyroidectomized rats. Reserpine, administered on a schedule designed to deplete catecholamine stores, altered the time course of plasma FFA changes only slightly. The results indicate that both the pituitary and adrenal functions are required for the expression of the rebound phenomenon after nicotinic acid administration. |
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Authors:
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J N Pereira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 8 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1967 May |
Date Detail:
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Created Date: 1967-10-22 Completed Date: 1967-10-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 239-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Catecholamines / metabolism Corticosterone / blood Dogs Fatty Acids / blood* Hypophysectomy Male Nicotinic Acids / pharmacology* Rats Reserpine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Fatty Acids; 0/Nicotinic Acids; 50-22-6/Corticosterone; 50-55-5/Reserpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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