Document Detail


The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles.
MedLine Citation:
PMID:  22826357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations are affected by the rate of LDL receptor-mediated clearance of apoB-containing particles. We measured apoM in humans each carrying one of three different LDL receptor mutations (n = 9) or the apoB3500 mutation (n = 12). These carriers had increased plasma apoM (1.34 ± 0.13 µM, P = 0.003, and 1.23 ± 0.10 µM, P = 0.02, respectively) as compared with noncarriers (0.93 ± 0.04 µM). When we injected human apoM-containing HDL into Wt (n = 6) or LDL receptor-deficient mice (n = 6), the removal of HDL-associated human apoM was delayed in the LDL receptor-deficient mice. After 2 h, 54 ± 5% versus 90 ± 8% (P < 0.005) of the initial amounts of human apoM remained in the plasma of Wt and LDL receptor-deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional catabolic rate of LDL (r = -0.38, P = 0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL receptor-mediated clearance of apoB-containing particles.
Authors:
Christina Christoffersen; Marianne Benn; Pernille M Christensen; Philip L S M Gordts; Anton J M Roebroek; Ruth Frikke-Schmidt; Anne Tybjaerg-Hansen; Björn Dahlbäck; Lars B Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-23
Journal Detail:
Title:  Journal of lipid research     Volume:  53     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-29     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2198-204     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins / blood*,  genetics,  metabolism
Apolipoproteins B / genetics,  metabolism*
Female
Humans
Lipocalins / blood*,  genetics,  metabolism
Lipoproteins, HDL / blood*,  metabolism
Lipoproteins, LDL / blood,  metabolism
Male
Mice
Mice, Inbred Strains
Mutation
Prospective Studies
Receptors, LDL / deficiency,  genetics*
Chemical
Reg. No./Substance:
0/APOM protein, human; 0/Apolipoproteins; 0/Apolipoproteins B; 0/Lipocalins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Receptors, LDL
Comments/Corrections

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