Document Detail


The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila.
MedLine Citation:
PMID:  14701683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell fate diversity is generated in part by the unequal segregation of cell-fate determinants during asymmetric cell division. In the Drosophila bristle lineage, the sensory organ precursor (pI) cell is polarized along the anteroposterior (AP) axis by Frizzled (Fz) receptor signaling. We show here that Fz localizes at the posterior apical cortex of the pI cell prior to mitosis, whereas Strabismus (Stbm) and Prickle (Pk), which are also required for AP polarization of the pI cell, co-localize at the anterior apical cortex. Thus, asymmetric localization of Fz, Stbm and Pk define two opposite cortical domains prior to mitosis of the pI cell. At mitosis, Stbm forms an anterior crescent that overlaps with the distribution of Partner of Inscuteable (Pins) and Discs-large (Dlg), two components of the anterior Dlg-Pins-Galphai complex that regulates the localization of cell-fate determinants. At prophase, Stbm promotes the anterior localization of Pins. By contrast, Dishevelled (Dsh) acts antagonistically to Stbm by excluding Pins from the posterior cortex. We propose that the Stbm-dependent recruitment of Pins at the anterior cortex of the pI cell is a novel read-out of planar cell polarity.
Authors:
Yohanns Bellaïche; Olivia Beaudoin-Massiani; Isabella Stuttem; François Schweisguth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  131     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-31     Completed Date:  2004-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-78     Citation Subset:  IM    
Affiliation:
Ecole Normale Supérieure, UMR 8542, 46, rue d'Ulm, 75230 Paris, Cedex 05, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Animals, Genetically Modified
Cell Polarity / genetics,  physiology*
DNA-Binding Proteins / genetics,  physiology
Drosophila / cytology*,  genetics,  physiology*
Drosophila Proteins / genetics,  physiology*
Frizzled Receptors
Genes, Insect
Green Fluorescent Proteins
Luminescent Proteins / genetics,  metabolism
Membrane Proteins / genetics,  physiology*
Mitosis
Models, Biological
Molecular Sequence Data
Receptors, G-Protein-Coupled
Recombinant Fusion Proteins / genetics,  metabolism
Sense Organs / cytology*,  physiology
Signal Transduction
Stem Cells / cytology,  physiology
Tumor Suppressor Proteins / genetics,  physiology
Vertebrates
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Luminescent Proteins; 0/Membrane Proteins; 0/Receptors, G-Protein-Coupled; 0/Recombinant Fusion Proteins; 0/Tumor Suppressor Proteins; 0/Vang protein, Drosophila; 0/fz protein, Drosophila; 0/prickle protein, Drosophila; 143513-41-1/discs large 1 protein, Drosophila; 147336-22-9/Green Fluorescent Proteins

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