| The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila. | |
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MedLine Citation:
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PMID: 14701683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell fate diversity is generated in part by the unequal segregation of cell-fate determinants during asymmetric cell division. In the Drosophila bristle lineage, the sensory organ precursor (pI) cell is polarized along the anteroposterior (AP) axis by Frizzled (Fz) receptor signaling. We show here that Fz localizes at the posterior apical cortex of the pI cell prior to mitosis, whereas Strabismus (Stbm) and Prickle (Pk), which are also required for AP polarization of the pI cell, co-localize at the anterior apical cortex. Thus, asymmetric localization of Fz, Stbm and Pk define two opposite cortical domains prior to mitosis of the pI cell. At mitosis, Stbm forms an anterior crescent that overlaps with the distribution of Partner of Inscuteable (Pins) and Discs-large (Dlg), two components of the anterior Dlg-Pins-Galphai complex that regulates the localization of cell-fate determinants. At prophase, Stbm promotes the anterior localization of Pins. By contrast, Dishevelled (Dsh) acts antagonistically to Stbm by excluding Pins from the posterior cortex. We propose that the Stbm-dependent recruitment of Pins at the anterior cortex of the pI cell is a novel read-out of planar cell polarity. |
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Authors:
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Yohanns Bellaïche; Olivia Beaudoin-Massiani; Isabella Stuttem; François Schweisguth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 131 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-31 Completed Date: 2004-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 469-78 Citation Subset: IM |
Affiliation:
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Ecole Normale Supérieure, UMR 8542, 46, rue d'Ulm, 75230 Paris, Cedex 05, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Animals, Genetically Modified Cell Polarity / genetics, physiology* DNA-Binding Proteins / genetics, physiology Drosophila / cytology*, genetics, physiology* Drosophila Proteins / genetics, physiology* Frizzled Receptors Genes, Insect Green Fluorescent Proteins Luminescent Proteins / genetics, metabolism Membrane Proteins / genetics, physiology* Mitosis Models, Biological Molecular Sequence Data Receptors, G-Protein-Coupled Recombinant Fusion Proteins / genetics, metabolism Sense Organs / cytology*, physiology Signal Transduction Stem Cells / cytology, physiology Tumor Suppressor Proteins / genetics, physiology Vertebrates |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Luminescent Proteins; 0/Membrane Proteins; 0/Receptors, G-Protein-Coupled; 0/Recombinant Fusion Proteins; 0/Tumor Suppressor Proteins; 0/Vang protein, Drosophila; 0/fz protein, Drosophila; 0/prickle protein, Drosophila; 143513-41-1/discs large 1 protein, Drosophila; 147336-22-9/Green Fluorescent Proteins |
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