Document Detail


The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression.
MedLine Citation:
PMID:  18443340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia is associated with an increased release of factors from the placental syncytium into maternal blood, including the antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin, the antifibrinolytic factor plasminogen activator inhibitor-1, prostanoids, lipoperoxides, cytokines, and microparticles. These factors are suggested to promote maternal endothelium dysfunction and are associated with placental damage in pregnancies also complicated with intrauterine growth restriction (IUGR). In this report, we briefly describe the interaction of syncytial factors with hypoxia, reactive oxygen species, and apoptosis in the pathophysiology of preeclampsia and IUGR. Given the critical role of the syncytium in these complications of pregnancy, we also present a novel methodology in which laser capture microdissection followed by Western blotting is used to assess levels of syncytial Fas ligand, a key protein in the apoptotic cascade.
Authors:
Seth Guller; Yula Y Ma; Han-Hsuan Fu; Graciela Krikun; Vikki M Abrahams; Gil Mor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1127     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-07-03     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Department of Obstetrics/Gynecology, Yale University School of Medicine, 333 Cedar Street, 339 FMB, P.O. Box 208063, New Haven, CT 06520-8063, USA. seth.guller@yale.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apoptosis
Fas Ligand Protein
Female
Fetal Growth Retardation / diagnosis,  pathology*
Gene Expression Regulation, Developmental*
Giant Cells / metabolism*
Humans
Lasers
Models, Biological
Neovascularization, Physiologic*
Placenta / metabolism*
Pre-Eclampsia / diagnosis,  pathology*
Pregnancy
Reactive Oxygen Species
Trophoblasts / metabolism
Grant Support
ID/Acronym/Agency:
HD33909/HD/NICHD NIH HHS; R56 HD033909/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fas Ligand Protein; 0/Reactive Oxygen Species
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inflammation and pregnancy: the role of toll-like receptors in trophoblast-immune interaction.
Next Document:  The medical management of menopause: to treat or not to treat?