Document Detail

The placental origins of sudden cardiac death.
MedLine Citation:
PMID:  22997261     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Most sudden cardiac deaths are due to cardiac arrhythmias, and abnormalities in the autonomic nervous system could underlie them. There is growing evidence that coronary heart disease is associated with alterations of fetal development as a result of variations in the processes of placentation that control fetal nutrition. We hypothesized that placental size would be associated with sudden cardiac death.
METHODS: We examined sudden cardiac death within the Helsinki Birth Cohort of 13 345 men and women.
RESULTS: One hundred eighty-seven (2.7%) men and 47 (0.7%) women had sudden unexplained cardiac death outside hospital. Sudden death was associated with a thin placenta, the hazard ratio being 1.47 [95% confidence interval (CI) 1.11-1.93, P = 0.006] for each g/cm(2) decrease in thickness. Sudden death was independently associated with poor educational attainment (P < 0.0001). Both of these associations were independent of socio-economic status in later life.
CONCLUSION: Sudden death may be initiated by impaired development of the autonomic nervous system in utero as a result of shallow invasion of the spiral arteries in the maternal endometrium and consequent fetal malnutrition.
David J P Barker; Gail Larsen; Clive Osmond; Kent L Thornburg; Eero Kajantie; Johan G Eriksson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-19
Journal Detail:
Title:  International journal of epidemiology     Volume:  41     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-03-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1394-9     Citation Subset:  IM    
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MeSH Terms
Birth Weight / physiology
Coronary Disease / epidemiology*,  etiology,  mortality
Death, Sudden, Cardiac / epidemiology*,  etiology
Fetal Development / physiology*
Fetal Nutrition Disorders / epidemiology*,  etiology
Finland / epidemiology
Placenta / growth & development
Placentation / physiology*
Socioeconomic Factors
Grant Support
MC_UP_A620_1017//Medical Research Council; //British Heart Foundation

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