| The placental component in early-onset and late-onset preeclampsia in relation to fetal growth restriction. | |
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MedLine Citation:
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PMID: 22565848 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To identify pathological placental differences between early-onset and late-onset preeclampsia, in relation to fetal growth restriction (FGR). METHODS: Placentas from patients with preeclampsia were analyzed for lesions of maternal vascular supply consistent with maternal underperfusion and lesions of fetal vascular supply consistent with fetal thrombo-occlusive disease. Findings were compared between patients who gave birth before 34 weeks (early-onset preeclampsia) and after 34 weeks (late-onset preeclampsia). RESULTS: Compared with the late-onset group (n = 93), the early-onset group (n = 37) had higher rates of FGR (62.2% vs 25.8%, P < 0.001) and lesions of maternal vascular supply (95% vs 60%, P < 0.001). Within the early-onset group, cases with FGR (n = 23) had more lesions of fetal vascular supply (47.8% vs 7%, P = 0.01), with similar high rates of lesions of maternal vascular supply (91% vs 100%) compared with those without FGR. Within the late-onset preeclampsia group, cases with FGR (n = 24) had higher rates of maternal vascular supply lesions (88% vs 51%, P = 0.003) than those without FGR, but similar rates of fetal vascular supply lesions (25% vs 16%, P = 0.32). CONCLUSION: The placental fetal vascular supply lesions in combination with maternal vascular lesions are more dominant in early-onset preeclampsia with FGR as compared with early-onset preeclampsia without FGR. © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Michal Kovo; Letizia Schreiber; Avi Ben-Haroush; Eran Gold; Abraham Golan; Jacob Bar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-4 |
Journal Detail:
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Title: Prenatal diagnosis Volume: - ISSN: 1097-0223 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. michalkovo@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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