Document Detail

The placental component in early-onset and late-onset preeclampsia in relation to fetal growth restriction.
MedLine Citation:
PMID:  22565848     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To identify pathological placental differences between early-onset and late-onset preeclampsia, in relation to fetal growth restriction (FGR). METHODS: Placentas from patients with preeclampsia were analyzed for lesions of maternal vascular supply consistent with maternal underperfusion and lesions of fetal vascular supply consistent with fetal thrombo-occlusive disease. Findings were compared between patients who gave birth before 34 weeks (early-onset preeclampsia) and after 34 weeks (late-onset preeclampsia). RESULTS: Compared with the late-onset group (n = 93), the early-onset group (n = 37) had higher rates of FGR (62.2% vs 25.8%, P < 0.001) and lesions of maternal vascular supply (95% vs 60%, P < 0.001). Within the early-onset group, cases with FGR (n = 23) had more lesions of fetal vascular supply (47.8% vs 7%, P = 0.01), with similar high rates of lesions of maternal vascular supply (91% vs 100%) compared with those without FGR. Within the late-onset preeclampsia group, cases with FGR (n = 24) had higher rates of maternal vascular supply lesions (88% vs 51%, P = 0.003) than those without FGR, but similar rates of fetal vascular supply lesions (25% vs 16%, P = 0.32). CONCLUSION: The placental fetal vascular supply lesions in combination with maternal vascular lesions are more dominant in early-onset preeclampsia with FGR as compared with early-onset preeclampsia without FGR. © 2012 John Wiley & Sons, Ltd.
Michal Kovo; Letizia Schreiber; Avi Ben-Haroush; Eran Gold; Abraham Golan; Jacob Bar
Related Documents :
20360278 - Pregnancy-related discontinuation of antidepressants and depression care visits among m...
17291588 - Effects of posttraumatic stress disorder on pregnancy outcomes.
16708738 - Postnatal depression and socio-cultural practices among postnatal mothers in kota bahru...
19880088 - Structural reflex zone therapy in pregnancy and childbirth: a new approach.
1522198 - Cruciate thinning of the zona pellucida for more successful enhancement of blastocyst h...
21256588 - Review: genetic manipulation of the rodent placenta.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-4
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-6     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The extragenic spacer length between the 5' and 3' ends of the transgene expression cassette affects...
Next Document:  Imaging of Protein Synthesis: In Vitro and In Vivo Evaluation of (44)Sc-DOTA-Puromycin.