| The placenta: transcriptional, epigenetic, and physiological integration during development. | |
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MedLine Citation:
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PMID: 20364099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The placenta provides critical transport functions between the maternal and fetal circulations during intrauterine development. Formation of this interface relies on coordinated interactions among transcriptional, epigenetic, and environmental factors. Here we describe these mechanisms in the context of the differentiation of placental cells (trophoblasts) and synthesize current knowledge about how they interact to generate a functional placenta. Developing an understanding of these pathways contributes to an improvement of our models for studying trophoblast biology and sheds light on the etiology of pregnancy complications and the in utero programming of adult diseases. |
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Authors:
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Emin Maltepe; Anna I Bakardjiev; Susan J Fisher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-04-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 120 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-04-21 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1016-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, 513 Parnassus Ave. HSE-1401, Box 1346, San Francisco, CA 94143-1346, USA. emin.maltepe@ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication Cell Lineage DNA Methylation Embryonic Development* Epigenesis, Genetic* Female Histones / metabolism Humans Maternal-Fetal Exchange Placenta / physiology* Pregnancy Transcription, Genetic* Uterus / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HD030367/HD/NICHD NIH HHS; HD055638/HD/NICHD NIH HHS; HD055764/HD/NICHD NIH HHS; HL64597/HL/NHLBI NIH HHS; KO8-HL33488/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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