| A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes. | |
| | |
MedLine Citation:
|
PMID: 17909063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The identification and functional characterization of tumor-specific genes is a prerequisite for the development of targeted cancer therapies. Using an integrated data mining and experimental validation approach for the discovery of new targets for antibody therapy of cancer, we identified PLAC1. PLAC1 is a placenta-specific gene with no detectable expression in any other normal human tissue. However, it is frequently aberrantly activated and highly expressed in a variety of tumor types, in particular breast cancer. RNAi-mediated silencing of PLAC1 in MCF-7 and BT-549 breast cancer cells profoundly impairs motility, migration, and invasion and induces a G1-S cell cycle block with nearly complete abrogation of proliferation. Knockdown of PLAC1 is associated with decreased expression of cyclin D1 and reduced phosphorylation of AKT kinase. Moreover, PLAC1 is localized on the surface of cancer cells and is accessible for antibodies which antagonize biological functions of this molecule. These features, in summary, make PLAC1 an attractive candidate for targeted immunotherapeutic approaches. |
| | |
Authors:
|
Michael Koslowski; Ugur Sahin; Rita Mitnacht-Kraus; Gerhard Seitz; Christoph Huber; Ozlem Türeci |
Related Documents
:
|
12725323 - Transcriptional activation of cyclin-dependent kinase inhibitor, p21waf1 gene by treatm... 11678653 - Catalytic inhibition of topoisomerase iialpha by demethylzeylasterone, a 6-oxophenolic ... 8839573 - Tribal-based cancer control activities. services and perceptions. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cancer research Volume: 67 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-10-02 Completed Date: 2007-10-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
|
Languages: eng Pagination: 9528-34 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine III, Division of Experimental and Translational Oncology, Johannes Gutenberg University, Mainz, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Breast Neoplasms
/
genetics*,
pathology Cell Cycle / genetics Cell Line, Tumor Cell Movement / genetics Cell Transformation, Neoplastic / genetics*, pathology Gene Expression Regulation, Neoplastic Humans Pregnancy Proteins / genetics* RNA, Small Interfering / genetics |
| Chemical | |
Reg. No./Substance:
|
0/PLAC1 protein, human; 0/Pregnancy Proteins; 0/RNA, Small Interfering |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dynamics of the immune reaction to pancreatic cancer from inception to invasion.
Next Document: Enhancement of antibody-dependent mechanisms of tumor cell lysis by a targeted activator of compleme...