Document Detail


A placenta for life.
MedLine Citation:
PMID:  22578825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chorioallantoic placenta is the defining organ of eutherians that has enabled prolonged intrauterine gestation. As such, normal placental development and function are essential for mammalian reproductive success. Reflecting the key role of this organ in providing nutrients to the embryo, the characteristic cell type that forms substantial parts of the placenta is called 'trophoblast' (from Greek trephein 'to feed' and blastos 'germinator'). However, in addition to regulating nutrient supply, the placenta also exerts a number of other pivotal functions that highlight the importance of normal trophoblast differentiation for a successful pregnancy. In this guest symposium, 'Trophoblast Development', several contributors summarize insights gained from recent studies in the mouse that have advanced our understanding of trophoblast biology. This includes how the earliest trophoblast cells are set aside to expand in a stem- or progenitor-cell compartment under tight genetic and epigenetic control and how subsequent differentiation into the various placental cell types is controlled to ensure normal placentation. The relevance of these contributions range from early developmental cell fate decisions, stem cell biology and placental development for healthy pregnancy to the impact of placental failures on long-term health, with important clinical implications for assisted reproductive technology procedures and pregnancy-associated complications.
Authors:
Rosalind John; Myriam Hemberger
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-04-05
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  25     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-05     Completed Date:  2012-11-05     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / genetics
Endocrine Cells / physiology
Epigenesis, Genetic
Female
Humans
Maternal-Fetal Exchange / physiology
Mice
Placenta / physiology*
Pregnancy
Signal Transduction
Trophoblasts / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
BBS/E/B/0000C230//Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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