Document Detail

The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances.
MedLine Citation:
PMID:  16635527     Owner:  NLM     Status:  MEDLINE    
We test the null hypothesis that the morphometric diffusive conductance of the placental villous membrane does not alter in pregnancies complicated by intrauterine growth restriction (IUGR) or pre-eclampsia (PE). Placentas were collected from cases of normotensive IUGR, pure PE, PE+IUGR and from control pregnancies. Microscopical fields on formalin-fixed, trichrome-stained histological sections were randomly sampled for location and orientation. Using stereological methods, the exchange surface areas of peripheral (terminal and intermediate) villi and their fetal capillaries and the arithmetic and harmonic mean thicknesses of the villous membrane (maternal aspect of trophoblast to luminal aspect of vascular endothelium) were estimated. An index of the variability in thickness of this membrane, and an estimate of its oxygen diffusive conductance, was derived secondarily. Group comparisons were drawn using two-way analysis of variance to identify main effects (of PE or IUGR) and interaction effects (between PE and IUGR). PE did not have significant effects on placental morphology and there were no significant effects of PE or IUGR on membrane thickness or its variability. In contrast, IUGR (with or without PE) was associated with reduced surface areas and this was the principal factor leading to a smaller membrane diffusive conductance in these placentas. When account was taken of fetal mass, specific conductance showed no effects of PE or IUGR despite the mass-specific conductance in pure IUGR placentas appearing to be smaller than that in controls. The decline in total conductances is indicative of perturbations operating at the levels of villous trophoblast and fetal vasculature and these may contribute to fetal hypoxic stress.
T M Mayhew; R Manwani; C Ohadike; J Wijesekara; P N Baker
Related Documents :
12383317 - Transvaginal ultrasonography in predicting placenta previa at delivery: a longitudinal ...
8916217 - Increased content of annexin ii (p36) and p11 in human placenta brush-border membrane v...
10985977 - In utero perfusing fraction maps in normal and growth restricted pregnancy measured usi...
16627297 - Ovulation, pregnancy, placentation and husbandry in the african elephant (loxodonta afr...
1778297 - The validation of a computerized system for the interpretation of the antepartum fetal ...
9795887 - Unconscious pregnancy fantasies as an underlying dynamism in panic disorder.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-24
Journal Detail:
Title:  Placenta     Volume:  28     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2007 Feb-Mar
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Centre for Integrated Systems Biology & Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Transport / physiology
Case-Control Studies
Chorionic Villi / pathology*,  physiopathology
Fetal Growth Retardation / pathology*,  physiopathology
Pre-Eclampsia / pathology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix.
Next Document:  The distinct temperament profiles of bipolar I, bipolar II and unipolar patients.