| The placenta in maternal hyperhomocysteinaemia. | |
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MedLine Citation:
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PMID: 10426649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is becoming increasingly apparent that mild or moderate hyperhomocysteinaemia may be associated with adverse perinatal complications and outcomes. The placental pathology in 14 pregnancies from 11 women diagnosed retrospectively to have hyperhomocysteinaemia, following a recent history of intrauterine fetal growth restriction, abruption or of thromboembolic disease, were reviewed. Most of the placental findings indicated abnormal placentation but these were not specific to maternal hyperhomocysteinaemia nor found in every placenta. Features observed included absence of trophoblast-induced physiological vascular changes, acute atherosis, intraluminal endovascular trophoblast in the third trimester, infarction, retroplacental haematoma formation and accelerated villous maturity. Uteroplacental vascular thrombosis was also seen. Three of the women had a subsequent pregnancy where they were treated empirically with folic acid, and these resulted in improved perinatal outcomes. The finding of placental pathology warrants investigation of the woman for hyperhomocysteinaemia. Further randomised controlled trials of folic acid supplementation in preventing pregnancy complications associated with hyperhomocysteinaemia should be conducted. |
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Authors:
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T Y Khong; W M Hague |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 106 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-08-11 Completed Date: 1999-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 273-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Histopathology, Adelaide Women's and Children's Hospital, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Hematoma / etiology Humans Hyperhomocysteinemia / complications*, pathology Placenta / blood supply, pathology Placenta Diseases / etiology* Pregnancy Pregnancy Complications / pathology Retrospective Studies Thrombosis / etiology, pathology |
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