Document Detail


Is placenta a good indicator of cadmium and lead exposure?
MedLine Citation:
PMID:  8896389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Distribution of lead and cadmium was studied in 25 placentas. Samples were taken from 6 different lobuli, and lead and cadmium concentrations were not determined by graphite furnace atomic absorption spectrometry. Lead and cadmium were not distributed uniformly, and the concentrations differed by a factor > or = 2 among different lobuli within the same placenta in 36% and 52% of the placentas, respectively. Placental lead and cadmium concentrations were also determined in homogenized samples from smelter (n = 49) and control (n = 53) areas in northern Sweden. Mean lead and cadmium concentrations were low, even in the smelter area (geometric means = 10 ng/g and 3 ng/g wet weight, respectively). The significant differences observed (i.e., higher blood lead concentrations in the smelter area during pregnancy and in umbilical cord blood) were not reflected in the placenta. We concluded, therefore, that the placenta is not a suitable organ to use for the monitoring of environmental exposure to lead. It could be used to monitor cadmium exposure, but if pregnancy outcome is to be studied, consideration should be given to the sampling procedure.
Authors:
B I Lagerkvist; S Sandberg; W Frech; T Jin; G F Nordberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of environmental health     Volume:  51     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  AIM; IM    
Affiliation:
Department of Environmental Medicine, Umeå University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Cadmium / analysis*
Cadmium Poisoning / prevention & control
Case-Control Studies
Environmental Monitoring / methods*
Female
Humans
Lead / analysis*
Lead Poisoning / prevention & control
Metallurgy
Placenta / chemistry*
Pregnancy
Pregnancy Complications / prevention & control
Pregnancy Outcome
Reproducibility of Results
Sweden
Tissue Distribution
Chemical
Reg. No./Substance:
7439-92-1/Lead; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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