Document Detail

A placebo controlled evaluation of L-tryptophan in depression in the elderly.
MedLine Citation:
PMID:  7407745     Owner:  NLM     Status:  MEDLINE    
Two groups of unmatched patients attached to a Geriatric Hospital suffering from mild to moderate depression considered suitable for drug therapy were randomly allocated either 6 grams L-tryptophan daily or a similar dose of identical placebo for six weeks on a double-blind basis. Ratings (HRS and a 7 point global evaluation) were made pretrial and fortnightly up to and including six weeks. Both groups steadily improved, but there was no statistical difference between the L-tryptophan patients and those receiving placebo. Therefore, it would appear that L-tryptophan is not an effective anti-depressant.
A J Cooper; S R Datta
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  25     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  386-90     Citation Subset:  IM    
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MeSH Terms
Depressive Disorder / drug therapy*
Psychiatric Status Rating Scales
Tryptophan / therapeutic use*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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