Document Detail

A placebo-controlled comparison between the bronchodilatory effects of ipratropium bromide inhaled as a dry powder and by metered dose inhaler in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  2973269     Owner:  NLM     Status:  MEDLINE    
A placebo-controlled study was performed to compare the effect of the inhalation of ipratropium bromide as a powder (capsule = 40 micrograms) and by pressurized aerosol (two puffs of 20 micrograms; ie, 40 micrograms). Fifteen patients (nine males and six females) with chronic obstructive pulmonary disease were studied in a double-blind crossover comparison of the two different modes of administration. The VC, FEV1 and viscous work of breathing time-response curves were almost identical, indicating bronchodilation. We conclude that in patients with chronic obstructive pulmonary disease, the powder inhalation was not more effective than the pressurized aerosol. It could, however, be offered as an alternative to patients with poor hand-lung coordination. The patients tolerated the two modes of administration without difficulties: no local irritation or coughing was observed.
F Gimeno; R van Veenen; W C Berg; E J Steenhuis
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Publication Detail:
Type:  Case Reports; Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of allergy     Volume:  61     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-08     Completed Date:  1988-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-3     Citation Subset:  IM    
Asthma Clinic, Beatrixoord Hospital, Haren (Gr.), The Netherlands.
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MeSH Terms
Administration, Inhalation
Atropine Derivatives / administration & dosage*
Forced Expiratory Volume
Ipratropium / administration & dosage*
Lung Diseases, Obstructive / drug therapy*
Middle Aged
Work of Breathing
Reg. No./Substance:
0/Aerosols; 0/Atropine Derivatives; 60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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