| The pituitary-thyroid axis in Klinefelter's syndrome. | |
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MedLine Citation:
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PMID: 401552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conventional thyroid function indices (serum T4, T3, TSH and thyroidal RAIU before and after TSH) appeared to be normal in most of 25 clinically euthyroid patients with chromatine positive Klinefelter's syndrome. Administration of TRH, however, revealed a decreased TSH reserve in the Klinefelter patients, both off or on testosterone treatment, in comparison to euthyroidal eugondal male controls. Preliminary data suggest that this blunted TSH respnse to TRH is not a characteristic of Klinefelter's syndrome per se but might be caused by the concurrent hypergonadotrophism. Despite the blunted TSH response, the TRH mediated T3 response in the Klinefelter patients was about equal to that in the male controls. |
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Authors:
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A G Smals; P W Kloppenborg; R L Lequin; L Beex; A Ross; T J Benraad |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 84 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1977-02-26 Completed Date: 1977-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 72-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Klinefelter Syndrome / drug therapy, physiopathology* Male Pituitary Gland / physiopathology* Pituitary Gland, Anterior / physiopathology*, secretion Secretory Rate Testosterone / therapeutic use Thyroid Gland / physiopathology* Thyrotropin / blood, secretion* Thyrotropin-Releasing Hormone / diagnostic use Thyroxine / blood, secretion* Triiodothyronine / blood, secretion* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 58-22-0/Testosterone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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