Document Detail

A pilot study to investigate any relationship between sustained maximal inspiratory pressure and extubation outcome.
MedLine Citation:
PMID:  11910389     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To establish whether any relationship exists between extubation outcome and sustained maximal inspiratory pressures (SMIP). DESIGN AND SETTING: Prospective clinical study in the 7-bed general intensive care unit of a university hospital. SUBJECTS: Twenty-seven intubated adults who were deemed ready for extubation were enrolled. MEASUREMENTS: Standard respiratory parameters and inspiratory muscle function data (ie, SMIP and peak maximal inspiratory pressures [MIP]) were recorded before extubation. RESULTS: SMIP was found to be significantly greater in those who were successfully extubated than in those who underwent a failed extubation (P <.01). Receiver operating characteristic curves for SMIP data indicated that a cutoff point of 57.5 pressure time units would give a sensitivity and specificity of 1.0 for extubation outcome prediction. Peak MIP was also significantly greater in those successfully extubated (P =.04); a cutoff point of 17.5 cm H(2)O gave a sensitivity of 1.0 and a specificity of 0.5. CONCLUSIONS: In this study, peak MIP was not specific enough to be clinically useful as a predictor of extubation outcome. SMIP was associated with extubation outcome with equally high sensitivity and specificity and may therefore have a role in outcome prediction.
Anne Bruton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  31     ISSN:  0147-9563     ISO Abbreviation:  Heart Lung     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-22     Completed Date:  2002-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-9     Citation Subset:  AIM; IM    
School of Health Professions and Rehabilitation Sciences, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
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MeSH Terms
Aged, 80 and over
Critical Illness
Follow-Up Studies
Inspiratory Capacity*
Intensive Care Units
Middle Aged
Pilot Projects
Predictive Value of Tests
Prospective Studies
ROC Curve
Respiration, Artificial
Respiratory Function Tests
Respiratory Muscles / physiology*
Risk Factors
Sensitivity and Specificity
Time Factors
Ventilator Weaning*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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