| A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206. | |
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MedLine Citation:
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PMID: 20495438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have reported improvement in lipids after antiretroviral therapy switches to tenofovir disoproxil fumarate (TDF)-containing regimens. We assessed lipid-lowering effects of TDF by adding it to a stable antiretroviral therapy regimen in this double-blind, placebo-controlled crossover study. We demonstrated that nonhigh-density lipoprotein cholesterol, low-density lipoprotein cholestrol, and total cholestrol improved significantly over TDF vs. placebo treatment in HIV-infected individuals with dyslipidemia. Adding TDF to stable, virologically suppressive antiretroviral therapy regimens improved lipid parameters, supporting a lipid-lowering effect of TDF. |
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Authors:
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Marisa Tungsiripat; Douglas Kitch; Marshall J Glesby; Samir K Gupta; John W Mellors; Laura Moran; Lynne Jones; Beverly Alston-Smith; James F Rooney; Judith A Aberg |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS (London, England) Volume: 24 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-08-19 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 1781-4 Citation Subset: IM; X |
Affiliation:
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Cleveland Clinic and Case Western Reserve University,Cleveland, Ohio 44195, USA. tungsim@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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analogs & derivatives*,
therapeutic use Adult Aged Anti-HIV Agents / therapeutic use* Antiretroviral Therapy, Highly Active / adverse effects, methods Cholesterol / blood Dyslipidemias / blood, drug therapy*, etiology Epidemiologic Methods Female HIV Infections / blood, complications, drug therapy* HIV-1* Humans Male Middle Aged Phosphonic Acids / therapeutic use* Pilot Projects Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1 U01 AI 069494/AI/NIAID NIH HHS; AI-068634/AI/NIAID NIH HHS; AI-069494/AI/NIAID NIH HHS; AI-069501/AI/NIAID NIH HHS; AI-070078/AI/NIAID NIH HHS; AI-25859/AI/NIAID NIH HHS; AI-27665/AI/NIAID NIH HHS; AI068636/AI/NIAID NIH HHS; AI069419/AI/NIAID NIH HHS; AI069428/AI/NIAID NIH HHS; AI069532/AI/NIAID NIH HHS; AI078884/AI/NIAID NIH HHS; AI25859/AI/NIAID NIH HHS; AI27665/AI/NIAID NIH HHS; AI38558/AI/NIAID NIH HHS; K23 AI070078-04/AI/NIAID NIH HHS; K23 AI070078-05/AI/NIAID NIH HHS; K24 AI078884-03/AI/NIAID NIH HHS; K24 AI078884-04/AI/NIAID NIH HHS; M01 RR000096-478543/RR/NCRR NIH HHS; M01RR00096/RR/NCRR NIH HHS; U01 AI027665-18S2/AI/NIAID NIH HHS; U01 AI038858-09S6/AI/NIAID NIH HHS; U01 AI068634-04/AI/NIAID NIH HHS; U01 AI068636-01/AI/NIAID NIH HHS; U01 AI068636-02/AI/NIAID NIH HHS; U01 AI068636-03/AI/NIAID NIH HHS; U01 AI068636-04/AI/NIAID NIH HHS; U01 AI069501-04/AI/NIAID NIH HHS; U01 AI069532-01/AI/NIAID NIH HHS; U01 AI069532-02/AI/NIAID NIH HHS; U01 AI069532-03/AI/NIAID NIH HHS; U01 AI069532-04/AI/NIAID NIH HHS; U01AI069495/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Phosphonic Acids; 0/tenofovir disoproxil; 57-88-5/Cholesterol; 73-24-5/Adenine |
| Comments/Corrections | |
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