Document Detail


A pilot study to determine genetic polymorphism in Mycobacterium tuberculosis isolates in Central India.
MedLine Citation:
PMID:  23183476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was carried out to identify predominant spoligotypes responsible for transmission and prevalence of tuberculosis in central India since there is no data available about the genetic biodiversity of Mycobacterium tuberculosis isolates from patients with tuberculosis in this region. 35 strains of Mycobacterium tuberculosis were subjected to spoligotyping according to the standard protocol. A total of 25 strains out of the 35 (71.42%) could be grouped in to 6 clusters. The largest cluster comprised 8 isolates. Unique (Non-clustered) spoligotypes were seen in 10 isolates, Nine strains did not match the data base (Spol DB-4 data base). The results indicate that there may be a number of orphan strains unique to this geographical area. Further studies on a larger sample size derived from this area would help us delineate the epidemiology of Mycobacterium tuberculosis infection in this area.
Authors:
P Desikan; D S Chauhan; P Sharma; N Panwalkar; S Gautam; V M Katoch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical microbiology     Volume:  30     ISSN:  1998-3646     ISO Abbreviation:  Indian J Med Microbiol     Publication Date:    2012 Oct-Dec
Date Detail:
Created Date:  2012-11-27     Completed Date:  2013-04-29     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8700903     Medline TA:  Indian J Med Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  470-3     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Karond, Bhopal, India.
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MeSH Terms
Descriptor/Qualifier:
Cluster Analysis
Genotype
Humans
India
Molecular Epidemiology
Molecular Typing*
Mycobacterium tuberculosis / classification*,  genetics*,  isolation & purification
Polymorphism, Genetic*
Tuberculosis / epidemiology*,  microbiology*
Comments/Corrections
Erratum In:
Indian J Med Microbiol. 2013 Jan-Mar;31(1):104

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