| A pilot study showing pulsed-dye laser treatment improves localized areas of chronic atopic dermatitis. | |
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MedLine Citation:
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PMID: 18201257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Eczematous skin changes overlying port-wine stains have been reported to improve with pulsed-dye laser (PDL) treatment. However, PDL has not as yet been evaluated for the treatment of atopic dermatitis (AD; eczema). AIM: To evaluate in a controlled trial the effects and safety of PDL treatment in children with AD who had chronic localized lesions. METHODS: Twelve children with localized, chronic eczema were treated with PDL (595 nm), with untreated areas used as an intrapatient control. Treatment was given at baseline and patients were followed up at 2 and 6 weeks. Clinical outcome measures were localized Eczema Severity Score (ESS), a visual analogue scale (VAS) indicating eczema severity assessed by photographs, and adverse events. RESULTS: After 2 and 6 weeks, a significant decrease in ESS was seen for the PDL-treated areas compared with the control areas (mean +/- SEM reduction in ESS 7.0 +/- 1.0 vs. 3.3 +/- 0.8 at 2 weeks, P = 0.003, and 7.8 +/- 1.4 vs. 4.9 +/- 1.3 at 6 weeks, P = 0.002). A significant difference in eczema severity assessed by VAS at 6 weeks was seen in favour of PDL (mean +/- SEM improvement 78% +/- 20% vs. 52% +/- 10%, P = 0.003). Treatment was well-tolerated. CONCLUSIONS: In this pilot study, PDL treatment was effective in treating small areas of chronic localized eczema. This may suggest that in AD dermal vasculature plays an important role or that PDL may have an effect on cutaneous immunological activation. |
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Authors:
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S Syed; L Weibel; H Kennedy; J I Harper |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-14 |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 33 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 243-8 Citation Subset: IM |
Affiliation:
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Department of Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Dermatitis, Atopic / radiotherapy* Dose-Response Relationship, Radiation Emollients / therapeutic use Female Humans Laser Therapy, Low-Level* Lasers, Dye / therapeutic use* Male Pilot Projects Port-Wine Stain / radiotherapy* Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Emollients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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