| A pilot study of screening for neuroblastoma in the north of England. | |
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MedLine Citation:
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PMID: 1456400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point. |
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Authors:
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A W Craft; L Parker; G Dale; A C McGill; J A Seviour; S Bell; M Cole; J Smith |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of pediatric hematology/oncology Volume: 14 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-07 Completed Date: 1993-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-41 Citation Subset: IM |
Affiliation:
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Department of Child Health, University of Newcastle Upon Tyne, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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England
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epidemiology Female Homovanillic Acid / urine Humans Infant Male Mass Screening / methods* Neuroblastoma / diagnosis*, mortality, urine Pilot Projects Predictive Value of Tests Vanilmandelic Acid / urine |
| Chemical | |
Reg. No./Substance:
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306-08-1/Homovanillic Acid; 55-10-7/Vanilmandelic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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