Document Detail


A pilot study of ranolazine in patients with intermittent claudication.
MedLine Citation:
PMID:  17164742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: This pilot study provides preliminary information regarding safety and changes in exercise performance during treatment with ranolazine extended-release in patients with reproducible claudication during exercise treadmill testing (ETT). METHODS: We enrolled 45 patients with documented peripheral arterial disease, reproducible claudication on ETT, and ankle-brachial indices <0.85 at rest that decreased by at least 0.15% or 20% immediately postexercise. Randomized patients received double-blind treatment with either ranolazine 1 000 mg b.i.d. (n=22) or placebo (n=23) for 4 weeks. RESULTS: Compared with baseline, peak walking time (PWT) increased (mean+/-SEM) by 53+/-34 s with ranolazine (P=0.13) and by 41+/-33 s with placebo (P=0.22). Pain-free walking time during ETT increased by 62+/-18 s with ranolazine (P=0.002) and 36+/-18 s with placebo (P=0.045). Supplemental analyses, excluding patients with baseline exercise duration (16 min and (12 min, showed additional improvement with ranolazine on PWT. CONCLUSIONS: Ranolazine was well tolerated and these data provide a rationale for proceeding with a definitive trial.
Authors:
A Ma; W T Garland; W B Smith; S Skettino; M T Navarro; A Q Chan; B E Anderson; J P Cooke
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  25     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-06-21     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  361-9     Citation Subset:  IM    
Affiliation:
Stanford University School of Medicine, Stanford, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetanilides / therapeutic use*
Adult
Aged
Aged, 80 and over
Double-Blind Method
Female
Humans
Intermittent Claudication / drug therapy*
Male
Middle Aged
Pilot Projects
Piperazines / therapeutic use*
Grant Support
ID/Acronym/Agency:
M01 RR00070/RR/NCRR NIH HHS; R01 HL-63685/HL/NHLBI NIH HHS; R01 HL-75774/HL/NHLBI NIH HHS; T32 HL07708/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Acetanilides; 0/Piperazines; 110445-25-5/ranolazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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